{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:16:21Z","timestamp":1784823381183,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>The safety, tolerability, immunogenicity, and pharmacokinetic (PK) profile of an anti\u2010OX40L monoclonal antibody (KY1005, currently amlitelimab) were evaluated. Pharmacodynamic (PD) effects were explored using keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT) immunizations. Sixty\u2010four healthy male subjects (26.5\u00a0\u00b1\u00a06.0\u00a0years) were randomized to single doses of 0.006, 0.018, or 0.05\u00a0mg\/kg, or multiple doses of 0.15, 0.45, 1.35, 4, or 12\u00a0mg\/kg KY1005, or placebo (6:2). Serum KY1005 concentrations were measured. Antibody responses upon KLH and TT immunizations and skin response upon intradermal KLH administration were performed. PD data were analyzed using repeated measures analysis of covariances (ANCOVAs) and post hoc exposure\u2010response modeling. No serious adverse events occurred and all adverse events were temporary and of mild or moderate severity. A nonlinear increase in mean serum KY1005 concentrations was observed (median time to maximum concentration (T<jats:sub>max<\/jats:sub>) ~\u00a04\u00a0hours, geometric mean terminal half\u2010life (t\u00bd) ~\u00a024\u00a0days). Cutaneous blood perfusion (estimated difference (ED) \u221213.4 arbitrary unit (AU), 95% confidence interval (CI) \u221223.0 AU to \u22123.8 AU) and erythema quantified as average redness (ED \u22120.23 AU, 95% CI \u22120.35 AU to \u22120.11 AU) decreased after KY1005 treatment at doses of 0.45\u00a0mg\/kg and above. Exposure\u2010response analysis displayed a statistically significant treatment effect on anti\u2010KLH antibody titers (IgG maximum effect (E<jats:sub>max<\/jats:sub>) \u22120.58 AU, 95% CI \u22121.10 AU to \u22120.06 AU) and skin response (erythema E<jats:sub>max<\/jats:sub> \u22120.20 AU, 95% CI \u22120.29 AU to \u22120.11 AU). Administration of KY1005 demonstrated an acceptable safety and tolerability profile and PK analyses displayed a nonlinear profile of KY1005. Despite the observed variability, skin challenge response after KY1005 treatment indicated pharmacological activity of KY1005. Therefore, KY1005 shows potential as a novel pharmacological treatment in immune\u2010mediated disorders.<\/jats:p>","DOI":"10.1002\/cpt.2539","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T11:59:48Z","timestamp":1643457588000},"page":"1121-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["OX40L Inhibition Suppresses KLH\u2010driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof\u2010of\u2010Pharmacology for KY1005"],"prefix":"10.1111","volume":"111","author":[{"given":"Mahdi","family":"Saghari","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research  Leiden The Netherlands"},{"name":"Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Gal","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research  Leiden The Netherlands"},{"name":"Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Kymab Ltd.  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