{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:38:52Z","timestamp":1761917932800},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Patients with inflammatory rheumatic diseases (IRDs) do not have an increased risk for coronavirus disease 2019 (COVID\u201019) compared with the general population. However, it remains uncertain whether subgroups of patients with IRD using different immunosuppressive antirheumatic drugs carry a higher risk for severe COVID\u201019 compared with other patients with IRD. The aim of this study is to identify risk factors for severe COVID\u201019, requiring hospitalization in patients with IRD. This is a multicenter nested case control study conducted in the Netherlands. Cases are hospital known patients with IRD requiring hospitalization for COVID\u201019 between March 1, 2020, and May 31, 2020. Controls are hospital known patients with IRD not requiring hospitalization for COVID\u201019 in this period, included at a 4:1 ratio. Patient, disease, and treatment characteristics were extracted from electronic medical records and a questionnaire. Potential risk factors were analyzed using unconditional logistic regression, corrected for confounders and multiple testing. Eighty\u2010one cases and 396 controls were included. General risk factors of older age and obesity apply to patients with IRD as well (odds ratio (OR) for age \u2265 75 3.5, 95% confidence interval (CI) 1.9\u20136.3, OR for body mass index \u2265 40 4.5, 95% CI 1.5\u201314). No significantly increased ORs for COVID\u201019 hospitalization were found for any antirheumatic agent or IRD. A protective effect was found for use of methotrexate (OR 0.53, 95% CI 0.31\u20130.92). In conclusion, similar to the general population, elderly and obese patients with IRD have a higher risk for hospitalization for COVID\u201019. We did not identify a specific antirheumatic agent or IRD to increase the risk of COVID\u201019 hospitalization in patients with IRD, except for a possible protective effect of methotrexate.<\/jats:p>","DOI":"10.1002\/cpt.2551","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T16:48:56Z","timestamp":1644511736000},"page":"1061-1065","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of Risk Factors for COVID\u201019 Hospitalization in Patients With Anti\u2010Rheumatic Drugs: Results From a Multicenter Nested Case Control Study"],"prefix":"10.1111","volume":"111","author":[{"given":"Merel A. A.","family":"Opdam","sequence":"first","affiliation":[{"name":"Department of Rheumatology Sint Maartenskliniek Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Benoy","sequence":"additional","affiliation":[{"name":"Regional Rheumatology Centre M\u00e1xima Medical Centre Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise M.","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Sint Maartenskliniek Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Van Bijnen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Elisabeth\u2010TweeSteden Hospital Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Lamers\u2010Karnebeek","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Bernhoven, Uden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 A. 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