{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:15:16Z","timestamp":1789092916011,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Previous studies have suggested an association between sulfonylureas and an increased risk of cardiovascular death among patients with type 2 diabetes. A potential mechanism involves sulfonylurea\u2010induced ventricular arrhythmias (VAs). We conducted a systematic review of observational studies to determine whether the use of sulfonylureas, compared with the use of other antihyperglycemic drugs, is associated with the risk of VA (ventricular tachycardia, ventricular fibrillation, and premature ventricular complexes), cardiac arrest, and sudden cardiac death among patients with type 2 diabetes. Two independent reviewers searched MEDLINE, EMBASE, CINAHL Plus, CENTRAL, and ClinicalTrials.gov from inception to July 2021 for observational studies comparing sulfonylureas vs. other antihyperglycemic therapies or intraclass comparisons of sulfonylureas. Our systematic review included 17 studies (1,607,612 patients). Per Risk Of Bias In Non\u2010randomized Studies of Interventions (ROBINS)\u2010I, there were few high\u2010quality studies (2 studies at moderate risk of bias; 4 at serious risk; and 11 at critical risk). All studies at a moderate or serious risk of bias reporting comparisons with other therapies were consistent with an increased risk of VA. Sulfonylureas were associated with a higher risk of arrhythmia vs. dipeptidyl peptidase\u20104 inhibitors (adjusted hazard ratio (aHR): 1.52, 95% confidence interval (CI): 1.27\u20131.80) and of VA vs. metformin (aHR: 1.52, 95% CI: 1.10\u20132.13). One moderate quality study reported inconsistent results for a composite of cardiac arrest\/VA in analyses of US Medicaid claims and Optum claims data. Our systematic review suggests that, among higher\u2010quality observational studies, sulfonylureas are associated with an increased risk of VA. However, we identified few methodologically rigorous studies, underscoring the need for additional real\u2010world studies.<\/jats:p>","DOI":"10.1002\/cpt.2570","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T02:30:16Z","timestamp":1646274616000},"page":"1248-1257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sulfonylureas and the Risk of Ventricular Arrhythmias Among People with Type 2 Diabetes: A Systematic Review of Observational Studies"],"prefix":"10.1111","volume":"111","author":[{"given":"Nehal","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Center for Clinical Epidemiology Lady Davis Institute Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henok T.","family":"Ayele","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Center for Clinical Epidemiology Lady Davis Institute Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana H. Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology Lady Davis Institute Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Endocrinology Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Douros","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Center for Clinical Epidemiology Lady Davis Institute Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Medicine McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Institute of Clinical Pharmacology and Toxicology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian B.","family":"Filion","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Center for Clinical Epidemiology Lady Davis Institute Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Medicine McGill University Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"789","article-title":"A study of the effects of hypoglycemic agents on vascular complications in patients with adult\u2010onset diabetes. 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