{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:25:23Z","timestamp":1790871923320,"version":"4.1.0"},"reference-count":176,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI\/FFP\/6820"],"award-info":[{"award-number":["SFI\/FFP\/6820"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Depression is considered a major public health concern, where existing pharmacological treatments are not equally effective across all patients. The pathogenesis of depression involves the interaction of complex biological components, such as the immune system and the microbiota\u2010gut\u2010brain axis. Adjunctive lifestyle\u2010oriented approaches for depression, including physical exercise and special diets are promising therapeutic options when combined with traditional antidepressants. However, the mechanisms of action of these strategies are incompletely understood. Accumulating evidence suggests that physical exercise and specific dietary regimens can modulate both the immune system and gut microbiota composition. Here, we review the current information about the strategies to alleviate depression and their crosstalk with both inflammatory mechanisms and the gut microbiome. We further discuss the role of the microbiota\u2010gut\u2010brain axis as a possible mediator for the adjunctive therapies for depression through inflammatory mechanisms. Finally, we review existing and future adjunctive strategies to manipulate the gut microbiota with potential use for depression, including physical exercise, dietary interventions, prebiotics\/probiotics, and fecal microbiota transplantation.<\/jats:p>","DOI":"10.1002\/cpt.2581","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T12:04:13Z","timestamp":1647086653000},"page":"246-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Inflammation, Lifestyle Factors, and the Microbiome\u2010Gut\u2010Brain Axis: Relevance to Depression and Antidepressant Action"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-6613","authenticated-orcid":false,"given":"Francisco","family":"Donoso","sequence":"first","affiliation":[{"name":"Alimentary Pharmabiotic Centre Microbiome Ireland University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[{"name":"Alimentary Pharmabiotic Centre Microbiome Ireland University College Cork  Cork Ireland"},{"name":"Department of Anatomy &amp; Neuroscience University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Olavarr\u00eda\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Alimentary Pharmabiotic Centre Microbiome Ireland University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Alimentary Pharmabiotic Centre Microbiome Ireland University College Cork  Cork Ireland"},{"name":"Department of Anatomy &amp; Neuroscience University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Clarke","sequence":"additional","affiliation":[{"name":"Alimentary Pharmabiotic Centre Microbiome Ireland University College Cork  Cork Ireland"},{"name":"Department of Psychiatry &amp; Neurobehavioural Science University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH16115"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0038550"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0267-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32802-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122216-011613"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000243"},{"key":"e_1_2_11_10_1","first-page":"620","article-title":"Depression and anxiety disorders: benefits of exercise, yoga, and meditation","volume":"99","author":"Saeed S.A.","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102315"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104621"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-016-0048-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.06.008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.09.009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14720"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.167"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00948-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881117711708"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(91)90272-Z"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13016"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-320912"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13279"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.053"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.05.004"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-020-2193-1"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00875-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2018"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0337-x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba8555"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012427"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20081182"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19090960"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.2573"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.07.019"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.604179"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi6087"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.10.006"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12908"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4030"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.042"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.06.053"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02303-y"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0556-9"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.10.010"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.08.001"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2019.1643237"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2018_155"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320916657"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S221437"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32835a4206"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-7802.174891"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-019-00543-8"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00615-w"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-5185-8"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74934-9"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0466-x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6199"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5006-5"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12701"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25979"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103307"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.132"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955711795906888"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114570800967X"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01788-2"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1815-6"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.04.053"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.10.005"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17-00131"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1388-x"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442611"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12667"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01511"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666151208113700"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152312803476255"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453144"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.02.037"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.05.029"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12760"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2019-0016"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30138-3"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30357-6"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01153"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.02.009"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.02.001"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40317"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00034"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2020.102118"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.11.029"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11094"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.06.014"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062194"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479163"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.020"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.01.009"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2014.47827"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102938"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8101646"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666181001153605"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP276431"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2018.10.001"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113512"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0258-x"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2018.01.015"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0000000000000620"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.03.063"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1938214.107"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01670-1"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.12.008"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12385"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00078"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.03.044"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002294"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527315666151111124729"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.06.025"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112791"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.06.028"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmaa181"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.10.011"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.2174\/1745017902016010156"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2017.1411320"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.07.004"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010007"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0175"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.04.028"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319654"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.669638"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.640648"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.765485"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9860-4"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.12.023"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108552"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2018.4308"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150928155612"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.08.018"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.10.026"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01634A"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2006.07.004"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071908"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101146"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104673"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.66"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.08.019"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.03.023"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.09.013"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666141130205242"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170915141036"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-018-8032-4"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132055"},{"key":"e_1_2_11_153_1","first-page":"581","article-title":"Effect of probiotic supplements in women with gestational diabetes mellitus on inflammation and oxidative stress biomarkers: a randomized clinical trial","volume":"27","author":"Hajifaraji M.","year":"2018","journal-title":"Asia Pac J. Clin. Nutr."},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1607547"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30023-1"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0502-z"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.124"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i10.3072"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.05.003"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113422"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.07.006"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1616\/1476-2137.15880"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.75"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10722-2"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.12.031"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3810-0"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.08.011"},{"key":"e_1_2_11_168_1","first-page":"519","article-title":"Fecal microbiota transplantation in ulcerative colitis","volume":"82","author":"Blanchaert C.","year":"2019","journal-title":"Acta Gastroenterol. Belg."},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2020-0061"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2017.08.027"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1941711"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2019.1617267"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1999374"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30198-0"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4060-2"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158227"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106661"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.2581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:36:44Z","timestamp":1699346204000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.2581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":176,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cpt.2581"],"URL":"https:\/\/doi.org\/10.1002\/cpt.2581","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"assertion":[{"value":"2022-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}