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How is an alternative approach generated, what information is available, and which instructions are considered missing today to generate such an approach? This tutorial describes the considerations and path followed to create an early and feasible alternative to a TQT study using experience\u2010based insights from a successful application to the US Food and Drug Administration for GLPG1972, an ADAMTS\u20105 inhibitor, and discusses the approach used in light of the current guidelines and literature.<\/jats:p>","DOI":"10.1002\/cpt.2596","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T06:24:51Z","timestamp":1648707891000},"page":"310-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example"],"prefix":"10.1111","volume":"113","author":[{"given":"Claudia","family":"Meyer","sequence":"first","affiliation":[{"name":"Galapagos B.V.  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Dierick","sequence":"additional","affiliation":[{"name":"Galapagos NV  Mechelen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Gauderat","sequence":"additional","affiliation":[{"name":"Translational Medicine Division Servier  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Langenhorst","sequence":"additional","affiliation":[{"name":"Pharmetheus A.B.  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Sarr","sequence":"additional","affiliation":[{"name":"Pharmetheus A.B.  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