{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:27:06Z","timestamp":1788485226941,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG007269"],"award-info":[{"award-number":["U01HG007269"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["T32 HG008958"],"award-info":[{"award-number":["T32 HG008958"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>The <jats:bold>A<\/jats:bold>ge, <jats:bold>B<\/jats:bold>ody mass index, <jats:bold>C<\/jats:bold>hronic kidney disease, <jats:bold>D<\/jats:bold>iabetes mellitus, and <jats:italic>CYP2C19<\/jats:italic> <jats:bold>GENE<\/jats:bold>tic variants (ABCD\u2010GENE) score was developed to identify patients at risk for diminished antiplatelet effects with clopidogrel after percutaneous coronary intervention (PCI). The objective of this study was to validate the ability of the ABCD\u2010GENE score to predict the risk for atherothrombotic events in a diverse, real\u2010world population of clopidogrel\u2010treated patients who underwent PCI and received clinical <jats:italic>CYP2C19<\/jats:italic> genotyping to guide antiplatelet therapy. A total of 2,341 adult patients who underwent PCI, were genotyped for <jats:italic>CYP2C19<\/jats:italic>, and received treatment with clopidogrel across four institutions were included (mean age 64\u00a0\u00b1\u00a012\u00a0years, 35% women, and 20% Black). The primary outcome was major atherothrombotic events, defined as the composite of all\u2010cause death, myocardial infarction, ischemic stroke, stent thrombosis, or revascularization for unstable angina within 12\u00a0months following PCI. Major adverse cardiovascular events (MACE), defined as the composite of cardiovascular death, myocardial infarction, ischemic stroke, or stent thrombosis, was assessed as the secondary outcome. Outcomes were compared between patients with an ABCD\u2010GENE score \u2265\u00a010 vs. &lt;\u00a010. The risk of major atherothrombotic events was higher in patients with an ABCD\u2010GENE score \u2265\u00a010 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0505) vs. &lt;\u00a010 (<jats:italic>n<\/jats:italic>\u00a0=\u00a01,836; 24.6 vs. 14.7 events per 100 patient\u2010years, adjusted hazard ratio (HR) 1.66, 95% confidence interval (CI), 1.23\u20132.25, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The risk for MACE was also higher among patients with a score \u2265\u00a010 vs. &lt;\u00a010 (16.7 vs. 10.1 events per 100 patient\u2010years, adjusted HR 1.59, 95% CI 1.11\u20132.30, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013). Our diverse, real\u2010world data demonstrate diminished clopidogrel effectiveness in post\u2010PCI patients with an ABCD\u2010GENE score \u2265\u00a010.<\/jats:p>","DOI":"10.1002\/cpt.2612","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T09:24:36Z","timestamp":1650101076000},"page":"146-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of the ABCD\u2010GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi\u2010Site, Real\u2010World Investigation"],"prefix":"10.1111","volume":"112","author":[{"given":"Cameron D.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida 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Therapeutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"David Anderson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa L.","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida 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G.","family":"Malave","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitrin W.","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Mulrenin","sequence":"additional","affiliation":[{"name":"Division of Pharmacotherapy and Experimental Therapeutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Starostik","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber L.","family":"Beitelshees","sequence":"additional","affiliation":[{"name":"Department of Medicine and Program for Personalized and Genomic Medicine University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA"},{"name":"Division of Cardiovascular Medicine College of Medicine University of Florida Gainesville Florida 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