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Regulatory agencies worldwide warn against the use of certain medications in persons with G6PD deficiency, but in many cases, this information is conflicting, and the clinical evidence is sparse. This guideline provides information on using\n                    <jats:italic>G6PD<\/jats:italic>\n                    genotype as part of the diagnosis of G6PD deficiency and classifies medications that have been previously implicated as unsafe in individuals with G6PD deficiency by one or more sources. We classify these medications as high, medium, or low to no risk based on a systematic review of the published evidence of the gene\u2013drug associations and regulatory warnings. In patients with G6PD deficiency, high\u2010risk medications should be avoided, medium\u2010risk medications should be used with caution, and low\u2010to\u2010no risk medications can be used with standard precautions, without regard to G6PD phenotype. This new document replaces the prior Clinical Pharmacogenetics Implementation Consortium guideline for rasburicase therapy in the context of\n                    <jats:italic>G6PD<\/jats:italic>\n                    genotype (updates at:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.cpicpgx.org\">www.cpicpgx.org<\/jats:ext-link>\n                    ).\n                  <\/jats:p>","DOI":"10.1002\/cpt.2735","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T21:44:27Z","timestamp":1662068667000},"page":"973-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of\n                    <i>G6PD<\/i>\n                    Genotype"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-042X","authenticated-orcid":false,"given":"Roseann S.","family":"Gammal","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Massachusetts College of Pharmacy and Health Sciences  Boston Massachusetts USA"},{"name":"Department of Pharmacy and Pharmaceutical Sciences St. Jude Children\u2019s Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-7266","authenticated-orcid":false,"given":"Munir","family":"Pirmohamed","sequence":"additional","affiliation":[{"name":"MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics Institute of Systems, Molecular and Integrative Biology, University of Liverpool  Liverpool 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Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4020-7052","authenticated-orcid":false,"given":"Amanda L.","family":"Elchynski","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Arkansas Children\u2019s Hospital  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazeem A.","family":"Oshikoya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology College of Medicine, Lagos State University  Ikeja Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-9232","authenticated-orcid":false,"given":"Howard L.","family":"McLeod","sequence":"additional","affiliation":[{"name":"Intermountain Precision Genomics Intermountain Healthcare  St George Utah 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-3793","authenticated-orcid":false,"given":"Kelly E.","family":"Caudle","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences St. Jude Children\u2019s Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary V.","family":"Relling","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences St. Jude Children\u2019s Research Hospital  Memphis Tennessee 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