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Previous research suggests that providing AN women with feedback regarding fetal exposure to tobacco may further promote cessation. Transporters in the placenta regulate fetal exposure to nutrients and xenobiotics, including compounds associated with tobacco use. We examined whether prenatal tobacco use impacts transporter expression in the placenta, and whether this is influenced by fetal sex, degree of tobacco exposure, or transporter genotype. At delivery, we obtained placental samples from AN research participants who smoked cigarettes, used commercial chew or iqmik (oral tobacco), or did not use tobacco during pregnancy. Transporter expression was evaluated using qRT\u2010PCR and Western blotting and tested for correlations between transcript levels and urinary biomarkers of tobacco use. The impact of <jats:italic>BCRP\/ABCG2<\/jats:italic> and <jats:italic>OATP2B1\/SLCO2B1<\/jats:italic> genotypes on protein expression was also examined. Oral tobacco use was associated with decreased <jats:italic>P\u2010gp<\/jats:italic> and increased <jats:italic>MRP1<\/jats:italic>, <jats:italic>MRP3<\/jats:italic>, <jats:italic>LAT1<\/jats:italic>, and <jats:italic>PMAT<\/jats:italic> mRNA expression. Transcript levels of multiple transporters significantly correlated with tobacco biomarkers in maternal and fetal urine. In women carrying male fetuses, both smoking and oral tobacco were associated with decreased P\u2010gp. Oral tobacco was also associated with decreased LAT1 in women carrying female fetuses. <jats:italic>BCRP<\/jats:italic> and <jats:italic>OATP2B1<\/jats:italic> genotypes did not appear to impact protein expression. In conclusion, prenatal tobacco use is associated with altered expression of multiple placental transporters which differs by fetal sex. As transcript levels of multiple transporters were significantly correlated with tobacco use biomarkers, eliminating prenatal tobacco use should alleviate these changes.<\/jats:p>","DOI":"10.1002\/cpt.2737","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T13:34:12Z","timestamp":1662125652000},"page":"634-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Effect of Tobacco Use on the Expression of Placental Transporters in Alaska Native Women"],"prefix":"10.1111","volume":"113","author":[{"given":"Eliza R.","family":"McColl","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinda","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-8124","authenticated-orcid":false,"given":"Neal L.","family":"Benowitz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Center for Tobacco Control Research and Education University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi A.","family":"Patten","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Behavioral Health Research Program Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Behavioral Health Research Program Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn R.","family":"Koller","sequence":"additional","affiliation":[{"name":"Clinical and Research Services, Division of Community Health Services Alaska Native Tribal Health Consortium (ANTHC)  Anchorage Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie A.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Clinical and Research Services, Division of Community Health Services Alaska Native Tribal Health Consortium (ANTHC)  Anchorage Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy K.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Clinical and Research Services, Division of Community Health Services Alaska Native Tribal Health Consortium (ANTHC)  Anchorage Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Y.","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"Research Department Southcentral Foundation (SCF)  Anchorage Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-2053","authenticated-orcid":false,"given":"Rachel F.","family":"Tyndale","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Toxicology, and Psychiatry, Centre for Addiction and Mental Health, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheline","family":"Piquette\u2010Miller","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457123"},{"key":"e_1_2_9_2_1","unstructured":"State of Alaska Pregnancy Risk Assessment Monitoring System.Maternal Cigarette Smoking Report 2012\u20132015. 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