{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:37:51Z","timestamp":1791945471698,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Most pharmacogenetic research is conducted in adult, non\u2010pregnant populations of European ancestry. Study of more diverse and special populations is necessary to validate findings and improve health equity. However, there are significant barriers to recruitment of diverse populations for genetic studies, such as mistrust of researchers due to a history of unethical research and ongoing social inequities. Engaging communities and understanding community members' perspectives may help to overcome these barriers and improve research quality. Here, we highlight one method for engaging communities, the Community Engagement Studio (CES), a consultative session that allows researchers to obtain guidance and feedback based on community members' lived experiences. We also provide an example of its use in pharmacogenetic studies. In designing a survey study of knowledge and attitudes around pharmacogenetic testing among children with chronic conditions and pregnant individuals, we sought input from diverse community stakeholders through CESs at Vanderbilt University Medical Center. We participated in two CESs with community stakeholders representing study target populations. Our goals were to learn specific concerns about pharmacogenetic testing and preferred recruitment strategies for these communities. Concerns were expressed about how genetic information would be used beyond the immediate study. Participants emphasized the importance of clarity and transparency in communication to overcome participation hesitancy and mistrust of the study team. Recruitment strategy recommendations ranged from informal notices posted in healthcare settings to provider referrals. The CES enabled us to modify our recruitment methods and research materials to better communicate with populations currently under\u2010represented in pharmacogenetics research.<\/jats:p>","DOI":"10.1002\/cpt.2792","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T08:18:38Z","timestamp":1668154718000},"page":"607-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tutorial: Using Community Engagement Studios to Enhance Pharmacogenetic Study Design for Maximizing Enrollment of Diverse Children and Pregnant People"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-0951","authenticated-orcid":false,"given":"Elizabeth A.","family":"Jasper","sequence":"first","affiliation":[{"name":"Division of Quantitative Sciences, Department of Obstetrics and Gynecology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina E.","family":"Holley","sequence":"additional","affiliation":[{"name":"Center for Pediatric Precision Medicine, Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Jones","sequence":"additional","affiliation":[{"name":"Institute for Medicine and Public Health Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Israel","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-1405","authenticated-orcid":false,"given":"Sara L.","family":"Van Driest","sequence":"additional","affiliation":[{"name":"Center for Pediatric Precision Medicine, Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Departments of Pediatrics and Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digna R.","family":"Velez Edwards","sequence":"additional","affiliation":[{"name":"Division of Quantitative Sciences, Department of Obstetrics and Gynecology Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Institute for Medicine and Public Health Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Genetics Institute Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Biomedical Informatics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ca2bbf"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.09.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/538161a"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1491"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2357"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1509"},{"key":"e_1_2_8_7_1","first-page":"951","article-title":"The legacy of Tuskegee and trust in medical care: is Tuskegee responsible for race differences in mistrust of medical care?","volume":"97","author":"Brandon D.T.","year":"2005","journal-title":"J. Natl. Med. Assoc."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1999.07048.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.13554"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0000000000000794"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0b013e3182441680"},{"key":"e_1_2_8_12_1","unstructured":"Israel T. Farrow H. Joosten Y.&Vaughn Y.Community Engagement Studio Toolkit 2.0. <https:\/\/www.meharry\u2010vanderbilt.org\/sites\/vumc.org.meharry\u2010vanderbilt\/files\/public_files\/CESToolkit%202.0.pdf> (2018)."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/cts.2021.785"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20179"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.11.1351"},{"issue":"1","key":"e_1_2_8_16_1","first-page":"S42","article-title":"Characterization of the ontogeny of hepatic UDP\u2010glucuronosyltransferase enzymes based on Glucuronidation activity measured in human liver Microsomes","volume":"59","author":"Badee J.","year":"2019","journal-title":"J. Clin. 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