{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:14:58Z","timestamp":1790046898709,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Comparative effectiveness evaluation of newer P2Y12 inhibitors (prasugrel and ticagrelor) compared with clopidogrel after acute coronary syndrome (ACS) is limited in real\u2010world US populations. The objective of this study was to evaluate cardiovascular events based on ticagrelor, prasugrel, and clopidogrel use in a real\u2010world patient setting. This retrospective cohort study used the IBM MarketScan database (January 1, 2013, to December 31, 2018) to create three propensity score\u2010matched pairs: ticagrelor vs. clopidogrel (<jats:italic>N<\/jats:italic>\u00a0=\u200921,719), prasugrel vs. clopidogrel (<jats:italic>N<\/jats:italic>\u00a0=\u200911,513), and prasugrel vs. ticagrelor (<jats:italic>N<\/jats:italic>\u00a0=\u200911,065). The primary outcome was a composite of myocardial ischemia, unstable angina, stroke, and heart failure hospitalization. These groups were compared in a time\u2010to\u2010event analysis for the primary outcome at 30, 90, and 180\u2009days following P2Y12 inhibitors initiation after percutaneous coronary intervention. Compared with clopidogrel, ticagrelor use suggested a 10% reduction in the primary outcome at 90\u2009days (hazard ratio (HR): 0.90, 95% confidence interval (CI): 0.82\u20130.99). There were no differences for all other matched pairs or follow\u2010up combinations. In the subgroup analysis of females, the results suggested a risk reduction of 27% for prasugrel at 30\u2009days (HR: 0.73, 95% CI: 0.53\u20131.00) and 17% for ticagrelor at 90\u2009days (HR: 0.83, 95% CI: 0.70\u20130.98) when compared with clopidogrel. Among patients treated with bare\u2010metal stents, the results suggested that prasugrel vs. ticagrelor was associated with a 55% and 33% reduced risk for the primary outcome at 30\u2009days and 180\u2009days, respectively. With limited evidence in the United States comparing these drugs, this study helps inform clinicians when choosing P2Y12 inhibitors after ACS.<\/jats:p>","DOI":"10.1002\/cpt.2797","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T14:28:54Z","timestamp":1668781734000},"page":"401-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative Effectiveness of Ticagrelor, Prasugrel, and Clopidogrel for Secondary Prophylaxis in Acute Coronary Syndrome: A Propensity <scp>Score\u2010Matched<\/scp> Cohort Study"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-3479","authenticated-orcid":false,"given":"Arun","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice &amp; Administrative Sciences James L. Winkle College of Pharmacy, University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-1340","authenticated-orcid":false,"given":"Pamela L.","family":"Lutsey","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health School of Public Health, University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2201-3019","authenticated-orcid":false,"given":"Wendy L.","family":"St Peter","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care and Health Systems College of Pharmacy, University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-4221","authenticated-orcid":false,"given":"Jon C.","family":"Schommer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care and Health Systems College of Pharmacy, University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-3685","authenticated-orcid":false,"given":"Jeremy R.","family":"Van't Hof","sequence":"additional","affiliation":[{"name":"Cardiovascular Division and Lillehei Heart Institute University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-0246","authenticated-orcid":false,"given":"Abhijeet","family":"Rajpurohit","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care and Health Systems College of Pharmacy, University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-5238","authenticated-orcid":false,"given":"Joel F.","family":"Farley","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care and Health Systems College of Pharmacy, University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.513"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0906549"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072771.11429.83"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.057"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007497"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz898"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.799981"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30474-X"},{"key":"e_1_2_10_11_1","unstructured":"Administration USFD.Real\u2010World Evidence: Real\u2010world data (RWD) and real\u2010world evidence (RWE) are playing an increasing role in health care decisions<https:\/\/www.fda.gov\/science\u2010research\/science\u2010and\u2010research\u2010special\u2010topics\/real\u2010world\u2010evidence> (2020)."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-51455-6_20"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3334"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15857"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-3079"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2137284"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000735"},{"key":"e_1_2_10_18_1","unstructured":"The Healthcare Cost and Utilization Project (HCUP).Elixhauser Comorbidity Software Version 3.7<https:\/\/www.hcup\u2010us.ahrq.gov\/toolssoftware\/comorbidity\/comorbidity.jsp>"},{"key":"e_1_2_10_19_1","unstructured":"IBM Micromedex Red Book<https:\/\/www.ibm.com\/products\/micromedex\u2010red\u2010book> (2020)."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3263"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3386"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-05-0403"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.047498"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.6447"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908973"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014457"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307547"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2109"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.2797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:37:39Z","timestamp":1699364259000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.2797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cpt.2797"],"URL":"https:\/\/doi.org\/10.1002\/cpt.2797","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]},"assertion":[{"value":"2022-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}