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Genetic variation in\n CYP2D6<\/jats:italic>\n ,\n CYP2C19<\/jats:italic>\n , and\n CYP2B6<\/jats:italic>\n influences the metabolism of many of these antidepressants, which may potentially affect dosing, efficacy, and tolerability. In addition, the pharmacodynamic genes\n SLC6A4<\/jats:italic>\n (serotonin transporter) and\n HTR2A<\/jats:italic>\n (serotonin\u20102A receptor) have been examined in relation to efficacy and side effect profiles of these drugs. This guideline updates and expands the 2015 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for\n CYP2D6<\/jats:italic>\n and\n CYP2C19<\/jats:italic>\n genotypes and SSRI dosing and summarizes the impact of\n CYP2D6<\/jats:italic>\n ,\n CYP2C19<\/jats:italic>\n ,\n CYP2B6<\/jats:italic>\n ,\n SLC6A4<\/jats:italic>\n , and\n HTR2A<\/jats:italic>\n genotypes on antidepressant dosing, efficacy, and tolerability. We provide recommendations for using\n CYP2D6<\/jats:italic>\n ,\n CYP2C19<\/jats:italic>\n , and\n CYP2B6<\/jats:italic>\n genotype results to help inform prescribing these antidepressants and describe the existing data for\n SLC6A4<\/jats:italic>\n and\n HTR2A<\/jats:italic>\n , which do not support their clinical use in antidepressant prescribing.\n <\/jats:p>","DOI":"10.1002\/cpt.2903","type":"journal-article","created":{"date-parts":[[2023,4,9]],"date-time":"2023-04-09T23:30:00Z","timestamp":1681083000000},"page":"51-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":478,"title":["Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for\n CYP2D6<\/i>\n ,\n CYP2C19<\/i>\n ,\n CYP2B6<\/i>\n ,\n SLC6A4<\/i>\n , and\n HTR2A<\/i>\n Genotypes and Serotonin Reuptake Inhibitor Antidepressants"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-8696","authenticated-orcid":false,"given":"Chad A.","family":"Bousman","sequence":"first","affiliation":[{"name":"Department of Medical Genetics University of Calgary Calgary Alberta Canada"},{"name":"Department of Psychiatry University of Calgary Calgary Alberta Canada"},{"name":"Department of Physiology and Pharmacology University of Calgary Calgary Alberta Canada"},{"name":"Department of Community Health Sciences University of Calgary Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-1135","authenticated-orcid":false,"given":"James M.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-3961","authenticated-orcid":false,"given":"Laura B.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Clinical Pharmacology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Division of Patient Services Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-5843","authenticated-orcid":false,"given":"Katrin","family":"Sangkuhl","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2314-0164","authenticated-orcid":false,"given":"J. Kevin","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Individualized Cancer Management Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-2641","authenticated-orcid":false,"given":"Jeffrey R.","family":"Strawn","sequence":"additional","affiliation":[{"name":"Division of Patient Services Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Psychiatry & Behavioral Neuroscience University of Cincinnati Cincinnati Ohio USA"},{"name":"Division of Child & Adolescent Psychiatry Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajeet B.","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Medicine, IMPACT Institute Deakin University Burwood Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-4702","authenticated-orcid":false,"given":"Gualberto","family":"Rua\u00f1o","sequence":"additional","affiliation":[{"name":"Institute of Living at Hartford Hospital Hartford Connecticut USA"},{"name":"Department of Psychiatry University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-4400","authenticated-orcid":false,"given":"Daniel J.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8592-7790","authenticated-orcid":false,"given":"Evangelia Eirini","family":"Tsermpini","sequence":"additional","affiliation":[{"name":"Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-1058","authenticated-orcid":false,"given":"Jacob T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice & Pharmaceutical Sciences University of Minnesota College of Pharmacy Duluth Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian C.","family":"Bell","sequence":"additional","affiliation":[{"name":"Genome Medical South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-0504","authenticated-orcid":false,"given":"J. 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