{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:04Z","timestamp":1786977484554,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Aminoglycoside antibiotic exposure can result in ototoxicity and irreversible hearing loss among individuals that harbor the m.1555A&gt;G variant in the mitochondrial 12S rRNA gene,\n                    <jats:italic>MT\u2010RNR1<\/jats:italic>\n                    . Importantly, pre\u2010emptive m.1555A&gt;G screening has been shown to reduce the prevalence of pediatric aminoglycoside\u2010induced ototoxicity; however, professional guidelines to support and guide post\u2010test pharmacogenomic counseling in this context are not currently available. This Perspective highlights key issues with delivering\n                    <jats:italic>MT\u2010RNR1<\/jats:italic>\n                    results, including longitudinal familial care considerations and communicating m.1555A&gt;G heteroplasmy.\n                  <\/jats:p>","DOI":"10.1002\/cpt.2910","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T03:45:41Z","timestamp":1683171941000},"page":"262-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Pharmacogenomic\n                    <i>MT\u2010RNR1<\/i>\n                    Screening for Aminoglycoside\u2010Induced Ototoxicity and the Post\u2010Test Counseling Conundrum"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2505-9694","authenticated-orcid":false,"given":"Robert","family":"Rigobello","sequence":"first","affiliation":[{"name":"GeneDx  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4847-8374","authenticated-orcid":false,"given":"Jay","family":"Shaw","sequence":"additional","affiliation":[{"name":"GeneDx  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6642-8694","authenticated-orcid":false,"given":"Daniel","family":"Ilg","sequence":"additional","affiliation":[{"name":"GeneDx  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-1084","authenticated-orcid":false,"given":"Rebekah","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"GeneDx  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-1169","authenticated-orcid":false,"given":"Lisa","family":"Edelmann","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Kornreich","sequence":"additional","affiliation":[{"name":"GeneDx  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-1864","authenticated-orcid":false,"given":"Stuart A.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford California USA"},{"name":"Clinical Genomics Laboratory, Stanford Medicine  Palo Alta California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Cody","sequence":"additional","affiliation":[{"name":"GeneDx  Gaithersburg Maryland USA"},{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-00995-w"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12030421"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1913"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2309"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2022.0187"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.80"},{"key":"e_1_2_8_7_1","volume-title":"Medical Genetics Summaries","author":"Dean L.","year":"2012"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Births: final data for 2020","volume":"70","author":"Osterman M.","year":"2021","journal-title":"Natl. 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Accessed March 30 2023."},{"key":"e_1_2_8_10_1","volume-title":"GeneReviews((R))","author":"Chinnery P.F.","year":"1993"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.945352"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbaa025"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.2910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:38:08Z","timestamp":1699346288000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.2910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/cpt.2910"],"URL":"https:\/\/doi.org\/10.1002\/cpt.2910","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]},"assertion":[{"value":"2023-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}