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This study aimed to explore the clinical features of adverse drug events (ADEs) associated with eltrombopag in different age groups using individual case safety reports (ICSRs) from the World Health Organization database VigiBase and the US Food and Drug Administration Adverse Event Reporting System database from 2008 to 2022 in combination with a meta\u2010analysis of data from randomized clinical trials in the literature from inception to July 28, 2022. We conducted disproportionality analyses by grouping patients into the following age groups: 0\u201317 (0\u201323\u2009months, 2\u201311\u2009years, and 12\u201317\u2009years), 18\u201364, and\u2009\u2265\u200965\u2009years. The ADEs about hepatobiliary disorders, thrombosis, skin and subcutaneous tissue disorders, infections, and so on were observed more differently in each age group. Meta\u2010analysis results showed differences in the four system organ classes between adults and children with ITP: infections and infestations, general disorders and administration site conditions, skin and subcutaneous tissue disorders, and investigations. The adverse drug reactions in the latest version of instructions were searched in the databases to analyze their postmarketing safety signal strength. We observed signals of elevated alanine aminotransferase, aspartate aminotransferase, and blood bilirubin levels in all age groups. For children, urinary tract infection and back pain showed signals. Due to the inherent limitations of pharmacovigilance studies, more experiments are needed to assess the risks of eltrombopag in different ages.<\/jats:p>","DOI":"10.1002\/cpt.2918","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T08:48:21Z","timestamp":1682239701000},"page":"201-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety Profile of Eltrombopag in Different Age Groups: An Analysis of <scp>Real\u2010World<\/scp> Pharmacovigilance and Randomized Clinical Trials"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-4748","authenticated-orcid":false,"given":"Han","family":"Qu","sequence":"first","affiliation":[{"name":"School of Pharmacy Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Clinical Pharmacy, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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