{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:13Z","timestamp":1786977553634,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    Loss\u2010of\u2010function (LoF) alleles of cytochrome P450 2C19 (\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    ), which are prevalent in East Asians, are linked to high platelet reactivity (HPR) phenotype and poor prognosis. We aimed to investigate the incremental predictive value of HPR combined with\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype in predicting outcomes after drug\u2010eluting stent (DES) implantation. The patients treated with platelet function and genotype\u2010related long\u2010term prognosis in drug\u2010eluting stent (PTRG\u2010DES) consortium enrolled a total of 13,160 Korean patients treated with DES who had platelet function test (PFT) or\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype, of which, 6,717 patients with PFT and genotype together were categorized. HPR was defined as VerifyNow \u2265\u2009252 P2Y12 reaction unit. The primary outcome was the incidence of major adverse cardiac and cerebrovascular event (MACCE) 5\u2009years after treatment. The patients with both HPR and\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    LoF\/LoF had the highest MACCE rates (6.2%) and increased MACCE risk (adjusted hazard ratio: 1.89, 95% confidence interval: 1.20\u20132.91,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.006) compared with those without both HPR and\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    LoF\/LoF. There was no effect of interaction between HPR and\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype on the primary outcome (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.424). Adding combined HPR and\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype to the conventional model had an incremental influence in predicting MACCE and stent thrombosis. Compared to the model including HPR or\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotype alone, a combination model significantly improved the risk stratification for stent thrombosis but not MACCE. In DES\u2010treated East Asian patients, the combined evaluation of PFT results and\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotyping might improve risk prediction of ischemic events during clopidogrel treatment.\n                  <\/jats:p>","DOI":"10.1002\/cpt.3026","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:20:14Z","timestamp":1692649214000},"page":"1104-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["High Platelet Reactivity Combined with\n                    <i>CYP2C19<\/i>\n                    Genotype in Predicting Outcomes in East Asian Patients Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1111","volume":"114","author":[{"given":"Se\u2010Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital  Wonju South Korea"},{"name":"Severance Cardiovascular Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Sung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital  Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Hwa","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital  Wonju South 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Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u2010Sun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center Korea University Anam Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyuk","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine College of Medicine, Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwhi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital  Changwon South 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Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine, Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae\u2010Young","family":"Her","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kangwon National University School of Medicine  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dong\u2010A University Hospital  Busan South 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