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Parenteral artesunate (ARS) is the first\u2010line treatment for severe falciparum malaria. Since 2015, the World Health Organization has recommended individual doses of 3\u2009mg\/kg for children weighing &lt;\u200920\u2009kg. Recently, the US Food and Drug Administration (FDA) has challenged this recommendation, based on a simulated pediatric population, and argued for a lower dose in younger children (2.4\u2009mg\/kg). In this study, we performed population pharmacokinetic (PK) modeling of plasma concentration data from 80 children with severe falciparum malaria in the Democratic Republic of Congo who were given 2.4\u2009mg\/kg of ARS intravenously. Bayesian hierarchical modeling and a two\u2010compartment parent drug\u2010metabolite PK model for ARS were used to describe the population PKs of ARS and its main biologically active metabolite dihydroartemisinin. We then generated a virtual population representative of the target population in which the drug is used and simulated the total first\u2010dose exposures. Our study shows that the majority of younger children given the lower 2.4\u2009mg\/kg dose of intravenous ARS do not reach the same drug exposures as older children above 20\u2009kg. This finding supports withdrawal of the FDA's recent lower ARS dose recommendation as parenteral ARS is an extremely safe and well\u2010tolerated drug and there is potential for harm from underdosing in this rapidly lethal infection.<\/jats:p>","DOI":"10.1002\/cpt.3041","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T02:54:31Z","timestamp":1693882471000},"page":"1304-1312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evidence Based Optimal Dosing of Intravenous Artesunate in Children with Severe Falciparum Malaria"],"prefix":"10.1002","volume":"114","author":[{"given":"Ali","family":"Haghiri","sequence":"first","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"School of Engineering University of Leicester  Leicester 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