{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:12:58Z","timestamp":1790871178146,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Grants Council, University Grants Committee, Hong Kong","award":["HKU17104314"],"award-info":[{"award-number":["HKU17104314"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Thioamides antithyroid\u2010drugs (ATDs) are important in hyperthyroid disease management. Identification of the susceptibility locus of ATD\u2010induced agranulocytosis is important for clinical management. We performed a genome\u2010wide association study (GWAS) involving 20 patients with ATD\u2010induced agranulocytosis and 775 healthy controls. The top finding was further replicated. A single\u2010nucleotide polymorphism (SNP), rs185386680, showed the strongest association with ATD\u2010induced agranulocytosis in GWAS (odds ratio (OR) = 36.4; 95% confidence interval (CI) = 12.8\u2013103.7;\n                    <jats:italic>P<\/jats:italic>\n                    = 1.3 \u00d7 10\n                    <jats:sup>\u201024<\/jats:sup>\n                    ) and replication (OR = 37; 95% CI = 3.7\u2013367.4;\n                    <jats:italic>P<\/jats:italic>\n                    = 9.6 \u00d7 10\n                    <jats:sup>\u20107<\/jats:sup>\n                    ).\n                    <jats:italic>HLA\u2010B*38:02:01<\/jats:italic>\n                    was in complete linkage disequilibrium with rs185386680. High\u2010resolution HLA typing confirmed that\n                    <jats:italic>HLA\u2010B*38:02:01<\/jats:italic>\n                    was associated with carbimazole (CMZ)\/methimazole (MMI)\u2010induced agranulocytosis (OR = 265.5; 95% CI = 27.9\u20132528.0;\n                    <jats:italic>P<\/jats:italic>\n                    = 2.5 \u00d7 10\n                    <jats:sup>\u201014<\/jats:sup>\n                    ), but not associated with propylthiouracil (PTU). The positive and negative predictive values of\n                    <jats:italic>HLA\u2010B*38:02:01<\/jats:italic>\n                    in predicting CMZ\/MMI\u2010induced agranulocytosis were 0.07 and 0.999. Approximately 211 cases need to be screened to prevent one case. Screening for the risk allele will be useful in preventing agranulocytosis in populations in which the frequency of the risk allele is high.\n                  <\/jats:p>","DOI":"10.1002\/cpt.309","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T11:33:30Z","timestamp":1448364810000},"page":"555-561","source":"Crossref","is-referenced-by-count":60,"title":["<i>HLA\u2010B*38:02:01<\/i>\n                    predicts carbimazole\/methimazole\u2010induced agranulocytosis"],"prefix":"10.1111","volume":"99","author":[{"given":"C\u2010L","family":"Cheung","sequence":"first","affiliation":[{"name":"Pharmacogenomics and Precision Therapeutics Laboratory, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"},{"name":"The State Key Laboratory of Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"},{"name":"Department of Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"},{"name":"Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u2010W","family":"Sing","sequence":"additional","affiliation":[{"name":"Pharmacogenomics and Precision Therapeutics Laboratory, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CSM","family":"Tang","sequence":"additional","affiliation":[{"name":"Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"},{"name":"Department of Psychiatry, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VKF","family":"Cheng","sequence":"additional","affiliation":[{"name":"Pharmacogenomics and Precision Therapeutics Laboratory, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pirmohamed","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology The University of Liverpool  United Kingdom"},{"name":"Royal Liverpool and Broadgreen University Hospital NHS Trust Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u2010H","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital Hong Kong 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