{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:07:41Z","timestamp":1764047261493,"version":"3.40.5"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). As the management of pancreatitis is limited, clinical approaches focus on the prevention of post\u2010ERCP pancreatitis (PEP). In theory, the serine protease inhibitor nafamostat can reduce circulating inflammatory mediators in pancreatitis. We aimed to investigate the effect of nafamostat in the prevention of PEP in this systematic review and meta\u2010analysis. The protocol for this review was registered in PROSPERO (CRD42022367988). We systematically searched 5 databases without any filters on September 26, 2022. The eligible population was adult patients undergoing ERCP. We compared the PEP preventive effect of nafamostat to placebo. The main outcome was the occurrence of PEP. We calculated the pooled odds ratios (ORs), mean differences, and corresponding 95% confidence intervals (95% CIs) and multilevel model. The risk of bias was assessed using the Rob2 tool. Seven randomized controlled trials involving 2,962 patients were eligible for inclusion. Nafamostat reduced the overall incidence rate of PEP (20\u2009mg, OR: 0.50, 95% CI: 0.30\u20130.82 and 50\u2009mg, OR: 0.48, 95% CI: 0.24\u20130.96). However, the occurrence of mild PEP was significantly reduced only in the subgroup receiving 20\u2009mg nafamostat (OR, 0.49, 95% CI: 0.31\u20130.77). Overall, nafamostat therapy reduced moderate PEP in high\u2010risk patients (OR: 0.18, 95% CI: 0.0.4\u20130.84) and mild PEP in low\u2010risk patients (OR: 0.32, 95% CI: 0.17\u20130.61). Nafamostat is an effective therapy in the prevention of mild post\u2010ERCP pancreatitis. Further research is required to determine the cost\u2010effectiveness of this therapy.<\/jats:p>","DOI":"10.1002\/cpt.3118","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T17:49:10Z","timestamp":1701366550000},"page":"206-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nafamostat Reduces the Incidence of <scp>post\u2010ERCP<\/scp> Pancreatitis: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"115","author":[{"given":"Istv\u00e1n L\u00e1szl\u00f3","family":"Horv\u00e1th","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"University Pharmacy, Department of Pharmacy Administration Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9nes","family":"Kleiner","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"University Pharmacy, Department of Pharmacy Administration Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Nagy","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Heim P\u00e1l National Pediatric Institute  Budapest Hungary"},{"name":"Institute for Translational Medicine Medical School, University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Feh\u00e9rv\u00e1ri","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Biostatistics University of Veterinary Medicine  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Hank\u00f3","sequence":"additional","affiliation":[{"name":"University Pharmacy, Department of Pharmacy Administration Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine Medical School, University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Institute of Pancreatic Diseases Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-3333","authenticated-orcid":false,"given":"Dezs\u0151","family":"Csupor","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine Medical School, University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Institute of Clinical Pharmacy, Faculty of Pharmacy University of Szeged  Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-111319"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/145749691210100109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8992"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70740-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1075-4080"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74943-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.06.045"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.10.028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504702"},{"key":"e_1_2_10_11_1","first-page":"CD011384","article-title":"Pharmacological interventions for acute pancreatitis","volume":"4","author":"Moggia E.","year":"2017","journal-title":"Cochrane Database Syst. 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