{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:59:07Z","timestamp":1787162347802,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    We previously reported that an interferon (IFN)\u2010inducible protein, BST2, was regulated by the JAK\u2013STAT pathway activated by CD40, and subsequently suppressing hepatitis B virus (HBV) repliaction and transcription. The current research attempted to assess the impact of BST2 on the IFN\u2010treated anti\u2010HBV effect, and explore\n                    <jats:italic>BST2<\/jats:italic>\n                    variants for predicting pegylated IFN alpha (PegIFN\u03b1) therapy response of patients with hepatitis B e antigen (HBeAg)\u2010positive chronic hepatitis B (CHB). Using an HBV\u2010transfected cell model, the function of BST2 on HBV DNA replication and transcription driven by IFN was studied. The potentially functional\n                    <jats:italic>BST2<\/jats:italic>\n                    variants were selected through a strategy of gene\u2010wide screening. The associations of BST2 variants and polygenic score (PGS) model, which was used to quantify the combined influence of several genetic variants, with treatment response were examined in 2 separate PegIFN\u03b1\u2010treated cohorts of 238 and 707 patients with CHB, respectively. We found that overexpression of BST2 improved the anti\u2010HBV activity triggered by IFN\u2010\u03b1. Among PegIFN\u03b1\u2010treated patients with CHB,\n                    <jats:italic>BST2<\/jats:italic>\n                    _rs9576 was screened out to be significantly correlated with combined response (CR; i.e., HBeAg seroconversion along with HBV DNA level &lt;3.3log\n                    <jats:sub>10<\/jats:sub>\n                    IU\/mL,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20097.12\u2009\u00d7\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    ). Additionally, there was a strong correlation between the PGS incorporating\n                    <jats:italic>BST2<\/jats:italic>\n                    _rs9576 and other 5 genetic variations (previously described predictors of therapy response to PegIFN\u03b1) and CR (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20091.81\u2009\u00d7\u200910\n                    <jats:sup>\u221213<\/jats:sup>\n                    ), hepatitis B surface antigen (HBsAg) level (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.004), as well as HBsAg decline (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.017). In conclusion, higher BST2 expression responded better to IFN\u2010\u03b1 treatment.\n                    <jats:italic>BST2<\/jats:italic>\n                    _rs9576 is an effective indicator to forecast therapy response of PegIFN\u03b1\u2010treated patients with CHB. The PGS possesses the potential to boost the ability of PegIFN\u03b1 therapy response.\n                  <\/jats:p>","DOI":"10.1002\/cpt.3120","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T03:54:08Z","timestamp":1701230048000},"page":"361-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher\n                    <scp>BST2<\/scp>\n                    Expression Promotes the\n                    <scp>Anti\u2010HBV<\/scp>\n                    Effect of\n                    <scp>IFN<\/scp>\n                    \u2010\u03b1 and\n                    <i>BST2<\/i>\n                    Genetic Variant Predicts\n                    <scp>PegIFN\u03b1<\/scp>\n                    Treatment Response of\n                    <scp>HBeAg<\/scp>\n                    \u2010Positive Chronic Hepatitis B Patients"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-3085","authenticated-orcid":false,"given":"Jiaxuan","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"The Key Laboratory of Molecular Pathology (Hepatic Diseases) of Guangxi, Department of Pathology The Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-5161","authenticated-orcid":false,"given":"Jia","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-5108","authenticated-orcid":false,"given":"Rong","family":"Na","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-8736","authenticated-orcid":false,"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-8583","authenticated-orcid":false,"given":"Jinlin","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-2344","authenticated-orcid":false,"given":"De\u2010Ke","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"The Key Laboratory of Molecular Pathology (Hepatic Diseases) of Guangxi, Department of Pathology The Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-19"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22956"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302085"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.01.044"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.09.052"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.044"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15624"},{"key":"e_1_2_9_8_1","first-page":"1505","article-title":"A missense variant in Granulysin is associated with the 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