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To provide the current overview of AP culprit\u2010drugs to guide clinical practice, we reviewed the adverse event (AE) reports associated with AP in the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database from 2004 to 2022, and summarized a potential AP culprit\u2010drug list and its corresponding AE report quantity proportion. The disproportionality analysis was used to detect adverse drug reaction (ADR) signals for each drug in the drug list, and the ADR signal distribution was integrated to show the risk characteristic of drugs according to the ADR signal detection results. In the FAERS database, a total of 62,206 AE reports were AP\u2010related, in which 1,175 drugs were reported as culprit\u2010drug. On the whole, metformin was the drug with the greatest number of AE reports, followed by quetiapine, liraglutide, exenatide, and sitagliptin. Drugs used in diabetes was the drug class with the greatest number of AE reports, followed by immunosuppressants, psycholeptics, drugs for acid\u2010related disorders, and analgesics. In disproportionality analysis, 595 drugs showed potential AP risk, whereas 580 drugs did not show any positive ADR signal. According to the positive\u2013negative distribution of the ADR signal for drug classes, the drug class with the greatest number of positive drugs was antineoplastic agents. In this study, we provided the current comprehensive landscape of AP culprit\u2010drugs from the pharmacovigilance perspective, which can provide reference information for clinical practice.<\/jats:p>","DOI":"10.1002\/cpt.3139","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T07:52:07Z","timestamp":1702108327000},"page":"535-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Drug\u2010Induced Acute Pancreatitis: A Real\u2010World Pharmacovigilance Study Using the <scp>FDA<\/scp> Adverse Event Reporting System Database"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5215-5942","authenticated-orcid":false,"given":"Dongxuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Yongchuan Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmeng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"College of Pharmacy Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"College of Pharmacy Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60649-8"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i22.2902"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0158-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0087-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_10_6_1","first-page":"413","article-title":"Mortality prognostic factors in acute pancreatitis","volume":"9","author":"Popa C.C.","year":"2016","journal-title":"J. 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