{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:12:45Z","timestamp":1771330365173,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Concomitant use of sodium glucose cotransporter\u20102 inhibitors (SGLT\u20102i) and overactive bladder (OAB) drugs potentially poses a risk of urinary tract infections (UTIs) due to the urinary retention of highly concentrated glucose in the urine. Thus, this study aimed to investigate the risk of UTIs among patients who initiated SGLT\u20102i treatment while taking OAB drugs. This population\u2010based cohort study included new\u2010users of SGLT\u20102i or comparator antidiabetics (dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i); glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101RA)) with OAB drugs between 2014 and 2020 using claim data from Korea. Primary outcome was a composite UTI event composite end point comprising pyelonephritis, cystitis, and urethritis, using both inpatient and outpatient diagnoses. Propensity score fine stratification was used to adjust for potential confounding factors. Weighted hazard ratios (HR) were calculated using the Cox proportional hazards model. In the first cohort, 796 and 9,181 new\u2010users of SGLT\u20102i and DPP\u20104i with OAB drugs were identified, respectively. This study found a similar risk of UTIs in concomitant users of SGLT\u20102i and DPP\u20104i (weighted HR 1.08, 95% confidence interval: 0.88\u20131.32) with OAB drugs. In the second cohort, 2,387 and 280 new\u2010users of SGLT\u20102i and GLP\u20101RA with OAB drugs were identified, respectively. Initiation of SGLT\u20102i while on OAB treatment was not associated with increased risk of UTI (0.89, 0.50\u20131.60), compared with initiation of GLP\u20101RA. These results show that the concomitant use of SGLT\u20102i with OAB drugs was not associated with an increased risk of UTI compared with the concomitant use of DPP\u20104i or GLP\u20101RA with OAB drugs.<\/jats:p>","DOI":"10.1002\/cpt.3182","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T06:48:28Z","timestamp":1706510908000},"page":"1132-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Concomitant Use of\n                    <scp>Sodium\u2010Glucose<\/scp>\n                    Cotransporter 2 Inhibitors and Overactive Bladder Drugs and the Risk of Urinary Tract Infection"],"prefix":"10.1002","volume":"115","author":[{"given":"Sungho","family":"Bea","sequence":"first","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyesung","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"},{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohee","family":"Park","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"},{"name":"Research Department of Practice and Policy UCL School of Pharmacy  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Min","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Suk","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Korea University College of Medicine, Ansan Hospital  Ansan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-5412","authenticated-orcid":false,"given":"Katsiaryna","family":"Bykov","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-7525","authenticated-orcid":false,"given":"Ju\u2010Young","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"},{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation, Samsung Advanced Institute for Health Sciences &amp; Technology Sungkyunkwan University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032662"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-3-549"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-017-0234-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000309"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.803970"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831050-00002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2115011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.031"},{"key":"e_1_2_12_9_1","unstructured":"Administration USFaD 2015<https:\/\/www.fda.gov\/drugs\/drug\u2010safety\u2010and\u2010availability\/fda\u2010revises\u2010labels\u2010sglt2\u2010inhibitors\u2010diabetes\u2010include\u2010warnings\u2010about\u2010too\u2010much\u2010acid\u2010blood\u2010and\u2010serious> Accessed January 9 2023."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-3136"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14261"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-018-1116-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00052-8"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00186-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-009-0490-1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-016-0344-9"},{"key":"e_1_2_12_17_1","first-page":"799","article-title":"Data resource profile: the National Health Information Database of the National Health Insurance Service in South Korea","volume":"46","author":"Cheol Seong S.","year":"2017","journal-title":"Int. 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