{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:29:52Z","timestamp":1791944992174,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>The clinical impact of individual dose adjustment of mycophenolate mofetil is still debated, due to conflicting results from randomized clinical trials. This retrospective study aimed to compare 3\u2010year rejection\u2010free survival and adverse effects between adult kidney transplant recipients (KTRs) with or without mycophenolate mofetil model\u2010informed precision dosing (MIPD). MIPD is defined here as mycophenolic acid area under the curve (AUC<jats:sub>0\u201312h<\/jats:sub>) estimation using a limited sampling strategy, pharmacokinetic models and Bayesian estimators; dose recommendation to reach AUC<jats:sub>0\u201312h<\/jats:sub>\u2009=\u200945\u2009mg.h\/L; using a widely used online expert system. The study, nested in two multicenter prospective cohort studies, focused on patients who received a mycophenolate drug and were followed up for 1\u20133\u2009years. Mycophenolate mofetil MIPD was prescribed as per local practice, on a regular basis, when deemed necessary, or not at all. The MIPD group included 341 KTRs and the control group 392. At 3\u2009years, rejection\u2010free survival was respectively 91.2% and 80.6% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and the cumulative incidence of rejection 5.08% vs. 12.7% per patient\u2009\u00d7\u2009year (hazard ratio\u2009=\u20090.49 (0.34, 0.71), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), corresponding to a 2.5\u2010fold reduction. Significant association with rejection\u2010free survival was confirmed in patients at low or high risk of rejection (<jats:italic>P<\/jats:italic>\u2009=\u20090.017 and 0.013) and in patients on tacrolimus, but not on cyclosporine (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and 0.205). The mycophenolate mofetil MIPD group had significantly more adverse effects, but most occurred before the first AUC<jats:sub>0\u201312h<\/jats:sub>, suggesting some may be the reason why MIPD was ordered.<\/jats:p>","DOI":"10.1002\/cpt.3206","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T10:14:09Z","timestamp":1708337649000},"page":"351-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Better Rejection\u2010Free Survival at Three Years in Kidney Transplant Recipients With Model\u2010Informed Precision Dosing of Mycophenolate Mofetil"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-9180","authenticated-orcid":false,"given":"Claire","family":"Villeneuve","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France"},{"name":"Pharmacology &amp; Transplantation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1248 Universit\u00e9 de Limoges  Limoges France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT)  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Humeau","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1248 Universit\u00e9 de Limoges  Limoges France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT)  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Monchaud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France"},{"name":"Pharmacology &amp; Transplantation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1248 Universit\u00e9 de Limoges  Limoges France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT)  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-8904","authenticated-orcid":false,"given":"Marc","family":"Labriffe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France"},{"name":"Pharmacology &amp; Transplantation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1248 Universit\u00e9 de Limoges  Limoges France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT)  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010phillipe","family":"Rerolle","sequence":"additional","affiliation":[{"name":"Pharmacology &amp; Transplantation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1248 Universit\u00e9 de Limoges  Limoges France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT)  Limoges France"},{"name":"Department of Nephrology, Dialysis and Transplantation Centre Hospitalier Universitaire de Limoges  Limoges France"},{"name":"Department of Nephrology, Transplantation, Dialysis Centre Hospitalier Universitaire Pellegrin  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Couzi","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, UMR 5164 Immuno ConcEpT Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Fran\u00e7ois","family":"Westeel","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation University Hospital of Amiens  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Etienne","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Kamar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplantation Centre Hospitalier Universitaire de Toulouse  Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier  Toulouse France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1043, IFR\u2010BMT, Centre Hospitalier Universitaire Purpan  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"B\u00fcchler","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT)  Limoges France"},{"name":"Department of Nephrology and Kidney Transplantation University Hospital of Tours  Tours France"},{"name":"Fran\u00e7ois Rabelais University  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Thierry","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire SUrvival oPtimization in ORgan Transplantation (FHU SUPORT)  Limoges France"},{"name":"Department of Nephrology, Dialysis and Transplantation Centre Hospitalier Universitaire de Poitiers  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-0760","authenticated-orcid":false,"given":"Pierre","family":"Marquet","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France"},{"name":"Pharmacology &amp; 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