{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:24:46Z","timestamp":1789457086945,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    The beneficial effects of sodium\u2013glucose cotransporter 2 (SGLT2) inhibitors in patients with chronic kidney disease (CKD) with low albuminuria levels have not been established. This study aimed to compare the effects of dapagliflozin on kidney injury biomarkers in patients with CKD stratified by albuminuria level. We prospectively enrolled healthy volunteers (HVs;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920) and patients with CKD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200954) with and without diabetes mellitus. Patients with CKD were divided into two age\u2010matched and sex\u2010matched subgroups according to urinary albumin\u2013creatinine ratio (uACR) levels (&lt;300\u2009mg\/g and \u2265300\u2009mg\/g). The CKD group received dapagliflozin (10\u2009mg\/day). Urine samples were collected before treatment and after 3 and 6\u2009months of dapagliflozin. Urinary kidney injury molecule\u20101 (KIM\u20101), interleukin\u20101\u03b2 (IL\u20101\u03b2), and mitochondrial DNA nicotinamide adenine dinucleotide dehydrogenase subunit\u20101 (mtND1) copy number were measured. The estimated glomerular filtration rate (eGFR) of patients with CKD was lower than that of HVs (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). During the study period, eGFR decreased and uACR did not change in the CKD group. Kidney injury markers were significantly elevated in patients with CKD compared with those in HVs. Dapagliflozin reduced urinary KIM\u20101, IL\u20101\u03b2, and mtDNA copy number in patients with CKD after 6\u2009months of treatment. In further, the levels of urinary KIM\u20101 and IL\u20101\u03b2, patients with CKD decreased after 6\u2009months of dapagliflozin treatment regardless of albuminuria level. Dapagliflozin reduced urinary kidney injury biomarkers in patients with CKD, regardless of albuminuria level. These findings suggest that SGLT2 inhibitors may also attenuate the progression of low albuminuric CKD.\n                  <\/jats:p>","DOI":"10.1002\/cpt.3237","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T08:10:42Z","timestamp":1709799042000},"page":"1441-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dapagliflozin Reduces Urinary Kidney Injury Biomarkers in Chronic Kidney Disease Irrespective of Albuminuria Level"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2491-4701","authenticated-orcid":false,"given":"Junghyun","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Nephrology Soonchunhyang University Seoul Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5924-6908","authenticated-orcid":false,"given":"Seung Whan","family":"Doo","sequence":"additional","affiliation":[{"name":"Department of Urology Soonchunhyang University Seoul Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1815-6002","authenticated-orcid":false,"given":"Nayoung","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Nephrology Soonchunhyang University Seoul Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9757-2762","authenticated-orcid":false,"given":"Minsul","family":"Lee","sequence":"additional","affiliation":[{"name":"Hyonam Kidney Laboratory Soonchunhyang University Seoul Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-3961","authenticated-orcid":false,"given":"Haekyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology Soonchunhyang University Seoul 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