{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:12:55Z","timestamp":1789449175410,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    Digital therapeutics (DTx), evidence\u2010based software interventions for preventing, managing, or treating medical disorders, have rapidly evolved with healthcare's shift toward online, patient\u2010centric solutions. This study scrutinizes DTx clinical trials from 2005 to 2022, analyzing their growth, funding, underlying medical specialties, and other R&amp;D characteristics, using\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    data. Our analysis includes trials categorized via the ICD\u201011 system, covering active, recruiting, or completed studies and considering trials listing multiple conditions. In analyzing 5,889 registered DTx trials, we document a more than five\u2010fold increase in such trials since 2011, and a compound annual growth rate of 22.82% since 2005. While most trials were single\u2010center, the median number of study subjects increased in recent years, driven by larger interventional trials. The key disciplines driving this growth were psychiatry, neurology, oncology, and endocrinology. Mental health dominated DTx trials in recent years, led by neurocognitive disorders, substance abuse disorders, and mood disorders. Industry funding varied across disciplines and was particularly high in visual system diseases and dermatology. DTx trials have surged since 2005, accelerated by recent growth in mental health trials. These trends mirror developments toward remote healthcare delivery, amplified by digital health investments during the COVID\u201019 pandemic. Growing numbers of participants in DTx trials point to increased demand for more robust trials. However, because most trials are single\u2010center and country\u2010specific, more international cooperation and harmonized evaluation standards will be essential for DTx trials to become more efficient and provide validation across countries, health systems, and groups of individuals.\n                  <\/jats:p>","DOI":"10.1002\/cpt.3260","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:52:44Z","timestamp":1712058764000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tracing Digital Therapeutics Research Across Medical Specialties: Evidence from ClinicalTrials.gov"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-1415","authenticated-orcid":false,"given":"Lars","family":"Masanneck","sequence":"first","affiliation":[{"name":"Department of Neurology Medical Faculty University Hospital D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Digital Health Cluster, Hasso\u2010Plattner Institute  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-1041","authenticated-orcid":false,"given":"Ariel D.","family":"Stern","sequence":"additional","affiliation":[{"name":"Digital Health Cluster, Hasso\u2010Plattner Institute  Potsdam Germany"},{"name":"Technology and Operations Management Unit, Harvard Business School  Boston Massachusetts USA"},{"name":"Harvard\u2010MIT Center for Regulatory Science  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_10_1_1","volume-title":"Digital Health Technologies for Remote Data Acquisition in Clinical Investigations","author":"Center for Drug Evaluation and Research","year":"2022"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-023-00777-z"},{"key":"e_1_2_10_3_1","unstructured":"What is a DTx? 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