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Due to its rarity, formal studies to guide the diagnosis and management of parathyroid carcinoma are lacking. However, recent data from case reports, case series, and registry studies suggest the emergence of new and effective treatment approaches for this understudied disease. We reviewed existing literature on the diagnosis and management of parathyroid carcinoma. Our findings suggest that traditional approaches such as surgical resection for both localized and metastatic diseases continue to play an important role in patient management. For patients with unresectable disease, newer systemic treatment approaches, including the use of temozolomide and tyrosine kinase inhibitors, may offer clinical benefit.<\/jats:p>","DOI":"10.1002\/cpt.3432","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:17:32Z","timestamp":1725520652000},"page":"1496-1505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnosis and Management of Parathyroid Carcinoma"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5790-0767","authenticated-orcid":false,"given":"Alexander","family":"Lazzaro","sequence":"first","affiliation":[{"name":"Boston University Medical Center, Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-5273","authenticated-orcid":false,"given":"Grace (Qing)","family":"Zhao","sequence":"additional","affiliation":[{"name":"Section of Pathology and Laboratory Medicine Boston University Medical Center, Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-3977","authenticated-orcid":false,"given":"Matthew","family":"Kulke","sequence":"additional","affiliation":[{"name":"Section of Hematology and Oncology Boston University Medical Center, Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"334","article-title":"Parastruma maligna aberrata","volume":"100","author":"De Quervain F.","year":"1909","journal-title":"Langenbecks Arch. 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