{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:21:35Z","timestamp":1792524095721,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Researchers have studied potential corrected QT interval (QTc) prolongation from drug\u2013drug interactions (DDIs), raising unresolved questions about their real\u2010world impact. This retrospective case\u2010crossover study investigated the effects of QT\u2010prolonging drugs and DDIs on QTc prolongation in hospitalized patients aged 45\u2009years and above. The cohort comprised patients who had multiple hospitalizations and developed QTc prolongation (QTc\u2009&gt;\u2009500\u2009ms or an increase of &gt;60\u2009ms from baseline) at least 24\u2009hours after admission between 2011 and 2019. Conditional logistic regression compared drug exposure between hospitalizations with QTc prolongation (case window) and those without (reference window). Among 2,276 patients (mean age 71; 43.8% female), the use of QT\u2010prolonging drugs significantly increased the risk of QTc prolongation (odds ratio: 2.42 (95% confidence interval: 1.95\u20133.02)). The risk was higher with drugs of \u201cknown risks\u201d (OR: 3.78 (2.91\u20134.90)) and \u201cconditional risk\u201d (OR: 2.08 (1.65\u20132.62)). DDIs, particularly involving multiple \u201cknown risk\u201d drugs (OR: 7.86 (4.96\u201312.45)), strong cytochrome P450 enzyme inhibitors (OR: 5.57 (2.75\u201311.30)), or the concurrent use of \u22654 QT\u2010prolonging drugs with any risk (OR: 5.28 (3.96\u20137.03)) substantially increased the risk. Cautious prescribing for patients with multiple risk factors is important to minimize the likelihood of QTc prolongation. However, when considering enhanced monitoring or drug choices, it is crucial to carefully evaluate the overall risk of QT prolongation against the benefits of treatment to ensure optimal patient care.<\/jats:p>","DOI":"10.1002\/cpt.3469","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T07:55:21Z","timestamp":1728460521000},"page":"495-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Impact of <scp>QT<\/scp>\u2010Prolonging Medications and Drug\u2013Drug Interactions on <scp>QTc<\/scp> Interval Prolongation in Hospitalized Patients: A Case\u2010Crossover Study"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-7679","authenticated-orcid":false,"given":"Hsiu\u2010Ting","family":"Chien","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-7481","authenticated-orcid":false,"given":"Fang\u2010Ju","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"School of Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Pharmacy National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-7636","authenticated-orcid":false,"given":"Jyh\u2010Ming Jimmy","family":"Juang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Heart Failure Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-0850","authenticated-orcid":false,"given":"Shu\u2010Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"School of Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Pharmacy National Taiwan University Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03660.x"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00477-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2120"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.896"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032426"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000905"},{"key":"e_1_2_12_8_1","unstructured":"WoosleyRL HeiseCW GalloT WoosleyDandRomeroKA www.CredibleMeds.org QTdrugs List [Accessed Aug 31 2023] AZCERT Inc. 1 457 E. 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