{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:29:52Z","timestamp":1787596192480,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo\u2010HCT) is heterogeneous and influenced by various patient\u2010 and transplantation\u2010related factors, associated with poor prognoses for poor graft function (PGF) and isolated thrombocytopenia. Tailored interventions could improve the outcome of patients with PGF and post\u2010HCT thrombocytopenia. To provide individual predictions of 180\u2010day platelet counts from early phase data, we developed a model of long\u2010term platelet reconstitution after allo\u2010HCT. A large cohort (<jats:italic>n<\/jats:italic>\u2009=\u20091949) of adult patients undergoing their first allo\u2010HCT was included. Real\u2010world data from 1,048 retrospective patients were used for non\u2010linear mixed\u2010effects model development. Bayesian forecasting was used to predict platelet\u2013time profiles for 518 retrospective and 383 prospective patients during internal and external model validation, respectively. Thrombocytopenia was defined as mean platelet count &lt;\u200975\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, derived from the last 12 platelet measurements within the first 180\u2009days post\u2010HCT. Thrombocytopenia affected 37% of all patients and was associated with significantly reduced overall survival (<jats:italic>P<\/jats:italic>\u2010value &lt;\u20090.0001). On days +7, +14, +21, and\u2009+28, the developed model achieved areas under the receiver\u2010operating characteristic of \u2265\u20090.68, \u2265\u20090.75, \u2265\u20090.78, and 0.81 for the prediction of post\u2010HCT thrombocytopenia, respectively, with anti\u2010thymocyte globulin, donor relation, and total protein measurements representing prognostic markers for post\u2010HCT platelet kinetics. A publicly accessible web\u2010based demonstrator of the model was established (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/hsct.precisiondosing.de\">https:\/\/hsct.precisiondosing.de<\/jats:ext-link>). In summary, the developed model predicts individual platelet counts from day +28 post\u2010HCT adequately, utilizing internal and external datasets. The web\u2010based demonstrator provides a basis to implement model\u2010based predictions in clinical practice and to confirm these findings in future clinical studies.<\/jats:p>","DOI":"10.1002\/cpt.3580","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T13:25:22Z","timestamp":1738848322000},"page":"1413-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Model\u2010Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8963-4329","authenticated-orcid":false,"given":"Katharina M.","family":"G\u00f6tz","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin T.","family":"Turki","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation University Hospital Essen  Essen Germany"},{"name":"Department of Hematology and Oncology, Marienhospital University Hospital Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Och","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4126-0816","authenticated-orcid":false,"given":"Dominik","family":"Selzer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brossette","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Saarland University  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-323X","authenticated-orcid":false,"given":"Norbert","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Saarland University  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data &amp; Bioethics Fraunhofer Institute for Biomedical Engineering (IBMT)  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Theobald","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Saarland University  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Saarland University  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7171-4308","authenticated-orcid":false,"given":"Kerstin","family":"Rohm","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data &amp; Bioethics Fraunhofer Institute for Biomedical Engineering (IBMT)  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Weiler","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data &amp; Bioethics Fraunhofer Institute for Biomedical Engineering (IBMT)  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-2511","authenticated-orcid":false,"given":"Simeon","family":"R\u00fcdesheim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Saarland University  Saarbr\u00fccken Germany"},{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-075X","authenticated-orcid":false,"given":"Matthias","family":"Schwab","sequence":"additional","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology  Stuttgart Germany"},{"name":"Department of Clinical Pharmacology, Pharmacy and Biochemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Cluster of Excellence iFIT (EXC2180) \u201cImage\u2010guided and Functionally Instructed Tumor Therapies\u201d University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-6240","authenticated-orcid":false,"given":"Stephan","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data &amp; Bioethics Fraunhofer Institute for Biomedical Engineering (IBMT)  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute for Formal Ontology and Medical Information Science (IFOMIS) Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Riede","sequence":"additional","affiliation":[{"name":"Averbis GmbH  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Smola","sequence":"additional","affiliation":[{"name":"Institute of Virology Saarland University Medical Center  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich W.","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Kaddu\u2010Mulindwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1 University Hospital Saarland  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Rissland","sequence":"additional","affiliation":[{"name":"Institute of Virology Saarland University Medical Center  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Bittenbring","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1 University Hospital Saarland  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-1465","authenticated-orcid":false,"given":"Thorsten","family":"Lehr","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.07.014"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.05.036"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.257"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2427"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.917802"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3538-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.06.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.06.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2006.21.1.46"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704330"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03715-w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.218"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.229"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.02.021"},{"key":"e_1_2_10_15_1","first-page":"21","article-title":"XplOit: an ontology\u2010based data integration platform supporting the development of predictive models for personalized medicine","volume":"247","author":"Weiler G.","year":"2018","journal-title":"Stud. Health Technol. Inform."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26671"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6833"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.140"},{"key":"e_1_2_10_19_1","unstructured":"National Cancer Institute.Common terminology criteria for adverse events (CTCAE) version 5.0(2017) <https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm> Accessed April 9 2024."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-006-9035-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13132"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.05.023"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.11.034"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.226340"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.194"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJPP_138_2020"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.12.636"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1782"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.752"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1388"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018029454"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705623"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-1934-7"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2530-9"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0208-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12194"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12743"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.3597"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.8.2514"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13316"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1382-0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13262"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006775"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14722"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14260"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0427"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0715-9"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30029-7"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.3580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T21:49:54Z","timestamp":1744494594000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.3580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/cpt.3580"],"URL":"https:\/\/doi.org\/10.1002\/cpt.3580","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"2024-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}