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Despite the widespread use of QT\u2010prolonging drugs during pregnancy, the extent of heart rate (HR)\u2010corrected QT (QTc)\u00a0interval changes during normal pregnancy and preeclampsia remains unclear. This study aimed to quantify changes in QTc interval across different trimesters of normal pregnancy and third\u2010trimester preeclampsia. Eight databases were systematically searched from their inception to January 13, 2025. Any type of study design, except case reports\/series, reporting QT interval and HR or RR interval, and\/or QTc interval\u00a0for at least one trimester were included. Those reporting at least two trimesters or one trimester with nonpregnant controls were pooled in meta\u2010analyses using random\u2010effect models to calculate pooled mean differences (MD) across trimesters. Data from 57 studies (6,686 participants) were included with 33 studies (5,153 participants) pooled in meta\u2010analyses. Compared with nonpregnant individuals, QTc intervals increased across trimesters of normal pregnancy and in third\u2010trimester preeclampsia. Meta\u2010analyses revealed significant increases in QTc interval during first (MD\u2009=\u200910.0\u2009msec), second (MD\u2009=\u200920.2\u2009msec), and third trimesters (MD\u2009=\u200923.0\u2009msec) compared with nonpregnant individuals. Furthermore, preeclampsia increased the QTc interval by 21.7\u2009msec during the third trimester compared to normal pregnancy. No publication bias was detected, and the overall quality scores of most studies were fair (<jats:italic>n<\/jats:italic>\u2009=\u200923) or poor (<jats:italic>n<\/jats:italic>\u2009=\u200933). A significant QTc interval lengthening throughout normal pregnancy was identified, and to a greater extent during preeclampsia. The arrhythmogenicity in third\u2010trimester preeclampsia with a known risk for QTc interval prolongation, especially with using QT\u2010prolonging drugs, warrants further investigation.<\/jats:p>","DOI":"10.1002\/cpt.3605","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:11:41Z","timestamp":1741698701000},"page":"1650-1660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["QTc Interval Changes in Preeclampsia vs. Normal Pregnancy: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-3175","authenticated-orcid":false,"given":"Omar A.","family":"Aboshady","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Purdue University  West Lafayette Indiana USA"},{"name":"Clinical Pharmacology Department, Faculty of Medicine Menoufia University  Menoufia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1223-2910","authenticated-orcid":false,"given":"Jess Z.","family":"Raffa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Purdue University  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-0695","authenticated-orcid":false,"given":"Sara K.","family":"Quinney","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Purdue University  West Lafayette Indiana USA"},{"name":"Department of Obstetrics and Gynecology School of Medicine, Indiana University  Indianapolis Indiana USA"},{"name":"Division of Clinical Pharmacology, Department of Medicine, School of Medicine Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-9463","authenticated-orcid":false,"given":"James E.","family":"Tisdale","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Purdue University  West Lafayette Indiana USA"},{"name":"Division of Clinical Pharmacology, Department of Medicine, School of Medicine Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-9916","authenticated-orcid":false,"given":"Brian R.","family":"Overholser","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Purdue University  West Lafayette Indiana USA"},{"name":"Division of Clinical Pharmacology, Department of Medicine, School of Medicine Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.10.004"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00050-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.10.1322"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.12.014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15370"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMC.0000000000000204"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2018.85"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098253"},{"key":"e_1_2_9_9_1","first-page":"473","article-title":"Drug\u2010induced QT prolongation and Torsades de Pointes","volume":"42","author":"Li M.","year":"2017","journal-title":"P T"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmms.jmms_6_20"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606853"},{"key":"e_1_2_9_12_1","first-page":"17","article-title":"Electrocradiographic Qrs axis, Q wave and T\u2010wave changes in 2nd and 3rd trimester of normal pregnancy","volume":"8","author":"Sunitha M.S.","year":"2014","journal-title":"J. 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