{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:40:15Z","timestamp":1758948015711,"version":"3.44.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Germline pharmacogenetics (PGx) is increasingly used to tailor medication selection\/dosing. However, existing systems primarily communicate PGx results to providers, limiting direct patient engagement. To address this, we developed YourPGx Oncology, an innovative patient\u2010facing portal that delivers multi\u2010gene PGx results (<jats:italic>CYP2D6<\/jats:italic>, <jats:italic>UGT1A1<\/jats:italic>, <jats:italic>DPYD<\/jats:italic>) through 33 unique, patient\u2010friendly summaries. The utility of this tool was prospectively evaluated in an oncology population, where these pharmacogenes impact high\u2010stakes treatments. Patients enrolled in the PhOCus study (NCT04541381) participated in single\u2010session evaluations of the tool in\u2010person or via videoconference, with a pharmacist available for questions and administering pre\u2010 and post\u2010surveys that assessed educational impact. Each patient viewed their own previously obtained PGx results. Of 190 eligible patients, 70 responded to solicitations via email, phone, and in\u2010person, of whom 51 (73%) completed an observed session and completed surveys. Patients spent a median of 13.4\u2009minutes (range 8.1\u201321.0) navigating YourPGx Oncology. After portal interaction, patients' ability to identify individual efficacy and safety estimates for chemotherapies and pain medications significantly improved, with the proportion accurately recognizing PGx\u2010informed drug efficacy likelihoods rising from 32% to 72% (Odds Ratio [OR]\u2009=\u20095.8 for the shift from discordant to concordant efficacy knowledge, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and PGx\u2010related toxicity recognition increasing from 31% to 57% (OR\u2009=\u20093.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). Our findings show that a customized patient\u2010facing PGx results portal enhances patient understanding of individual medication efficacy and toxicity likelihoods, highlighting the potential key role of direct\u2010to\u2010patient PGx tools to facilitate optimized treatment\u2010informed care and promote genetically guided shared decision\u2010making.<\/jats:p>","DOI":"10.1002\/cpt.3747","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T02:50:32Z","timestamp":1751079032000},"page":"906-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of First\u2010of\u2010Its\u2010Kind Patient\u2010Facing Pharmacogenetics Tool on Dosing Decisions and Treatment Outcomes"],"prefix":"10.1002","volume":"118","author":[{"given":"Youngwoo","family":"Cho","sequence":"first","affiliation":[{"name":"Committee on Clinical Pharmacology and Pharmacogenomics University of Chicago  Chicago 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