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Cytokine release syndrome (CRS) is a systemic inflammatory response syndrome that is a well\u2010known complication of these therapies, of which interleukin\u20106 (IL\u20106) is a key mediator. Tocilizumab, an IL\u20106 receptor (IL\u20106R) antagonist, is approved for the management of CAR T\u2010cell therapy\u2010induced CRS in adults and in pediatric patients aged \u2265\u20092\u2009years old. However, the approved dosing schedule was not based on IL\u20106R occupancy and may not be the most suitable schedule for T\u2010cell\u2010engaging therapies such as bispecific antibodies (bsAb) due to key differences in the levels of released IL\u20106, the clinical symptomatology of CRS, and the pharmacology of tocilizumab across settings. In this study, we adapted a previously developed tocilizumab and soluble IL\u20106R (sIL\u20106R) population pharmacokinetic model to describe and predict tocilizumab concentrations and sIL\u20106R occupancy over time in patients with anti\u2010CD20 bsAb\u2010induced CRS following tocilizumab dosing. Using this model, which incorporates target binding and receptor occupancy, we propose a new tocilizumab dosing regimen that is based on quantitative clinical pharmacology, cytokine analyses, and clinical practice patterns in patients with relapsed\/refractory B\u2010cell non\u2010Hodgkin's lymphoma (R\/R B\u2010NHL) treated with the anti\u2010CD20 bsAb mosunetuzumab or glofitamab. This schedule (up to two 8\u2009mg\/kg intravenous tocilizumab doses per CRS event at least 8\u2009hours apart and a maximum of three doses in 6\u2009weeks) can be used to effectively manage acute CRS induced by anti\u2010CD20 bsAb in patients with R\/R B\u2010NHL.<\/jats:p>","DOI":"10.1002\/cpt.3751","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T10:54:38Z","timestamp":1751021678000},"page":"917-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tocilizumab Dosing for Management of T Cell\u2010Engaging Bispecific Antibody\u2010Related CRS in Patients With R\/R B\u2010Cell NHL"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-9687","authenticated-orcid":false,"given":"Candice","family":"Jamois","sequence":"first","affiliation":[{"name":"Roche Innovation Center Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-6188","authenticated-orcid":false,"given":"David C.","family":"Turner","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  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