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Lymphodepletion chemotherapy followed by infusion of T cells that are genetically modified to express a CD19\u2010specific CAR is a promising therapy for patients with refractory CD19<jats:sup>+<\/jats:sup> B\u2010cell malignancies, producing rates of complete remission that are remarkably high in acute lymphoblastic leukemia and encouraging in non\u2010Hodgkin lymphoma and chronic lymphocytic leukemia. Responses are often durable, although additional studies are needed to define the role of CAR\u2010T cell immunotherapy in the context of other treatments. CAR\u2010modified T\u2010cell immunotherapy can be complicated by cytokine release syndrome and neurologic toxicity, which in most cases are manageable and reversible. Here we review recent clinical trial data and discuss issues for the field.<\/jats:p>","DOI":"10.1002\/cpt.392","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T09:38:18Z","timestamp":1463045898000},"page":"252-258","source":"Crossref","is-referenced-by-count":66,"title":["CD19\u2010Targeted chimeric antigen receptor\u2010modified T\u2010cell immunotherapy for B\u2010cell malignancies"],"prefix":"10.1111","volume":"100","author":[{"given":"CJ","family":"Turtle","sequence":"first","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington USA"},{"name":"Department of Medicine University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SR","family":"Riddell","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington USA"},{"name":"Department of Medicine University of 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