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To identify novel variants implicated in on\u2010treatment platelet reactivity, patients with coronary artery disease (CAD) with extreme pharmacodynamic responses to clopidogrel and wild\u2010type <jats:italic>CYP2C19<\/jats:italic> were subjected to exome sequencing. Candidate variants that clustered in the LTPR subgroup subsequently were genotyped across the discovery cohort (<jats:italic>n<\/jats:italic> = 636). Importantly, carriers of <jats:italic>B4GALT2<\/jats:italic> c.909C&gt;T had lower on\u2010treatment P2Y12 reaction units (PRUs; <jats:italic>P<\/jats:italic> = 0.0077) and residual platelet aggregation (<jats:italic>P<\/jats:italic> = 0.0008) compared with noncarriers, which remained significant after adjusting for <jats:italic>CYP2C19<\/jats:italic> and other clinical variables in both the discovery (<jats:italic>P<\/jats:italic> = 0.0298) and replication (<jats:italic>n<\/jats:italic> = 160; PRU: <jats:italic>P<\/jats:italic> = 0.0001) cohorts. B4GALT2 is a platelet\u2010expressed galactosyltransferase, indicating that <jats:italic>B4GALT2<\/jats:italic> c.909C&gt;T may influence clopidogrel sensitivity through atypical cell\u2010surface glycoprotein processing and platelet adhesion.<\/jats:p>","DOI":"10.1002\/cpt.401","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T10:17:29Z","timestamp":1464085049000},"page":"287-294","source":"Crossref","is-referenced-by-count":28,"title":["Exome sequencing of extreme clopidogrel response phenotypes identifies <i>B4GALT2<\/i> as a determinant of on\u2010treatment platelet reactivity"],"prefix":"10.1111","volume":"100","author":[{"given":"SA","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010P","family":"Collet","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, Faculty of Medicine, UMRS_1166 ICAN Institute of Cardiometabolism and Nutrition AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Institute of Cardiology Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Baber","sequence":"additional","affiliation":[{"name":"Zena and Michael A. 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