{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:35:51Z","timestamp":1791999351991,"version":"4.4.0"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>\n                    Scientific interest in serotonergic psychedelics (e.g., psilocybin and LSD; 5\u2010HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor agonists) has dramatically increased within the last decade. Clinical studies administering psychedelics with psychotherapy have shown preliminary evidence of robust efficacy in treating anxiety and depression, as well as addiction to tobacco and alcohol. Moreover, recent research has suggested that these compounds have potential efficacy against inflammatory diseases through novel mechanisms, with potential advantages over existing antiinflammatory agents. We propose that psychedelics exert therapeutic effects for psychiatric disorders by acutely destabilizing local brain network hubs and global network connectivity via amplification of neuronal avalanches, providing the occasion for brain network \u201cresetting\u201d after the acute effects have resolved. Antiinflammatory effects may hold promise for efficacy in treatment of inflammation\u2010related nonpsychiatric as well as potentially for psychiatric disorders. Serotonergic psychedelics operate through unique mechanisms that show promising effects for a variety of intractable, debilitating, and lethal disorders, and should be rigorously researched.\n                  <\/jats:p>","DOI":"10.1002\/cpt.557","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T11:43:44Z","timestamp":1478259824000},"page":"209-219","source":"Crossref","is-referenced-by-count":311,"title":["Psychedelics as Medicines: An Emerging New Paradigm"],"prefix":"10.1111","volume":"101","author":[{"given":"DE","family":"Nichols","sequence":"first","affiliation":[{"name":"Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MW","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CD","family":"Nichols","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Sciences Center New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,26]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011478"},{"key":"e_1_2_10_2_1","first-page":"80","article-title":"LSD and the dying patient","volume":"26","author":"Kast E.","year":"1966","journal-title":"Chic. 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