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Currently, evidence supports cannabis and its active ingredients as immune\u2010modulating agents, affecting T\u2010cells, B\u2010cells, monocytes, and microglia cells, causing an overall reduction in pro\u2010inflammatory cytokine expression and an increase in anti\u2010inflammatory cytokines. Due to the supporting evidence of cannabinoids as an immune\u2010modulating agent, research focusing on cannabinoids and autoimmunity has emerged. Several clinical trials in multiple sclerosis, inflammatory bowel disease, and fibromyalgia suggest cannabis' effectiveness as an immune\u2010modulator. However, contradicting results and lack of large\u2010scale clinical trials obscure these results. Although lacking clinical research, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> experiments in rheumatoid arthritis, diabetes type 1, and systemic sclerosis demonstrate a correlation between disease activity and cannabinoids.<\/jats:p>","DOI":"10.1002\/cpt.568","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T19:59:39Z","timestamp":1479153579000},"page":"230-238","source":"Crossref","is-referenced-by-count":36,"title":["Medical cannabis: Another piece in the mosaic of autoimmunity?"],"prefix":"10.1111","volume":"101","author":[{"given":"D","family":"Katz","sequence":"first","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Faculty of Medicine The Hebrew University of Jerusalem  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Katz","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Faculty of Medicine The Hebrew University of Jerusalem  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BS","family":"Porat\u2010Katz","sequence":"additional","affiliation":[{"name":"The Robert H. 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