{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:32:44Z","timestamp":1787729564900,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Multiple Myeloma Opportunities for Research and Education (MMORE)","award":["46050-502048"],"award-info":[{"award-number":["46050-502048"]}]},{"name":"Ohio State University Comprehensive Cancer Center Core","award":["P30 CA016058"],"award-info":[{"award-number":["P30 CA016058"]}]},{"name":"Eli-Lilly fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>High\u2010dose melphalan followed by autologous stem cell transplantation remains the standard of care for eligible patients with multiple myeloma, but disease response and toxicity, including severe mucositis, varies among patients. Our randomized trial investigated duration of cryotherapy (2 and 6 h) for reduction of mucositis prevalence and severity and explored factors associated with variability in pharmacokinetics and outcomes from melphalan therapy. The results demonstrate that 2\u2010h is at least as effective as 6\u2010h cryotherapy in decreasing severe mucositis. From a population pharmacokinetic model, we identified that fat\u2010free mass, hematocrit, and creatinine clearance were significant covariates, as reported previously. Furthermore, we observed the rs4240803 <jats:italic>SLC7A5<\/jats:italic> polymorphism was significantly associated with pharmacokinetic variability, and pharmacokinetics was associated with both mucositis and neutropenia. However, melphalan exposure was not associated with progression\u2010free or overall survival in our dataset. These findings contribute to ongoing efforts to personalize melphalan dosing in transplant patients.<\/jats:p>","DOI":"10.1002\/cpt.644","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T08:16:50Z","timestamp":1486196210000},"page":"511-519","source":"Crossref","is-referenced-by-count":33,"title":["Associations of High\u2010Dose Melphalan Pharmacokinetics and Outcomes in the Setting of a Randomized Cryotherapy Trial"],"prefix":"10.1111","volume":"102","author":[{"given":"YK","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Pharmaceutics and Pharmaceutical Chemistry College of Pharmacy, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DW","family":"Sborov","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lamprecht","sequence":"additional","affiliation":[{"name":"Wexner Medical Center The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmaceutical Chemistry College of Pharmacy, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EM","family":"Hade","sequence":"additional","affiliation":[{"name":"Center for Biostatistics Department of Biomedical Informatics, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmaceutical Chemistry College of Pharmacy, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tackett","sequence":"additional","affiliation":[{"name":"Wexner Medical Center The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DM","family":"Benson","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YA","family":"Efebera","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AE","family":"Rosko","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SM","family":"Devine","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Poi","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Practice and Science College of Pharmacy, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CC","family":"Hofmeister","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Phelps","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmaceutical Chemistry College of Pharmacy, The Ohio State University Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350204"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022340"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00389-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood.V116.21.38.38","article-title":"Outcome with lenalidomide plus dexamethasone followed by early autologous stem cell transplantation in the ECOG E4A03 randomized clinical trial","volume":"116","author":"Siegel D.S.","year":"2010","journal-title":"Blood"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.56"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2201"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.257"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705384"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.02.025"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.08.012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.12.340"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705494"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03638.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.410"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.284"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(01)00384-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0021-9258(17)34167-4","article-title":"Active carrier\u2010mediated transport of melphalan by two separate amino acid transport systems in LPC\u20101 plasmacytoma cells in vitro","volume":"254","author":"Goldenberg G.J.","year":"1979","journal-title":"J. Biol. Chem."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.022"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.01.019"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1182\/blood.V124.21.3960.3960","article-title":"2\u2010hour cryotherapy effectively reduces severe mucositis associated with high\u2010dose melphalan followed by stem cell rescue: results from a randomized trial","volume":"124","author":"Sborov D.W.","year":"2014","journal-title":"Blood"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12906"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705471"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.03.026"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1629"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3280ea77cd"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-4-5-284"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-009-9102-7"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404284"},{"key":"e_1_2_9_29_1","volume-title":"Stata Statistical Software: Release 13","author":"StataCorp","year":"2013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt.644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:35:10Z","timestamp":1699364110000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,26]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/cpt.644"],"URL":"https:\/\/doi.org\/10.1002\/cpt.644","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,26]]}}}