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Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti\u2010seizure medication (ASM). The goal of this study was to evaluate the intrinsic anti\u2010epileptic and sedative properties of CBD. A randomized, double\u2010blind, placebo\u2010controlled, 3\u2010way crossover trial was conducted in 25 healthy males. On each visit, single doses of 30\u2009mg CBD, 700\u2009mg CBD, or placebo were administered orally. The effects of CBD on cortical excitability were measured using transcranial magnetic stimulation (TMS) combined with electromyography (EMG) and electroencephalography (EEG). Sedative properties were assessed using a validated CNS test battery. Pharmacokinetic sampling was performed. Data were analyzed using a mixed\u2010effects model. CBD did not have significant effects on single pulse and paired pulse TMS\u2010EMG parameters, compared to placebo. 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