{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:38:52Z","timestamp":1767004732992,"version":"3.48.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL149752"],"award-info":[{"award-number":["R01HL149752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG007269"],"award-info":[{"award-number":["U01HG007269"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Black individuals undergoing percutaneous coronary intervention (PCI) experience higher rates of major adverse cardiovascular events (MACE) than non\u2010Black individuals. This study assessed the racial differences in platelet reactivity and clinical outcomes among clopidogrel\u2010treated participants. Two cohorts were analyzed. The pharmacodynamic (PD) cohort involved patients with atherosclerotic cardiovascular disease on maintenance clopidogrel therapy undergoing platelet function testing. The primary outcome was high platelet reactivity (HPR, i.e., P2Y\n                    <jats:sub>12<\/jats:sub>\n                    reaction unit [PRU]\u2009&gt;\u2009208). The PCI cohort included participants undergoing PCI on clopidogrel\u2010based dual antiplatelet therapy. The primary outcome was 1\u2010year MACE, defined as the composite of cardiovascular death, myocardial infarction (MI), ischemic stroke, or stent thrombosis. Data on clinically significant bleeding and\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genotyping alleles were collected. The PD and PCI cohorts included 728 (32.1% Black) and 2,770 (20.5% Black) participants, respectively. Black participants had higher PRU levels (184 [IQR 128\u2013234] vs. 144 [IQR 88\u2013195];\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) and higher prevalence of HPR (39.3% vs. 20.6%;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Independent predictors of HPR included Black race, hemoglobin levels, and presence of\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    loss\u2010of\u2010function allele. In the PCI cohort, Black participants had a higher risk of MACE (HR 1.47; 95% CI 1.02\u20132.11;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.037), primarily driven by MI (HR 1.71; 95% CI 1.09\u20132.67;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.019), with no significant difference in clinically significant bleeding (HR 1.08; 95% CI 0.65\u20131.80;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.768). Black participants on clopidogrel exhibit higher platelet reactivity, increased rates of HPR, and an elevated risk of MACE within 1 year after PCI, without significant differences in bleeding compared to non\u2010Black participants.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70045","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T13:59:25Z","timestamp":1756389565000},"page":"168-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel\u2010Treated Participants"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-3253","authenticated-orcid":false,"given":"Luis","family":"Ortega\u2010Paz","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-2313","authenticated-orcid":false,"given":"Cameron D.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-7402","authenticated-orcid":false,"given":"Claudio","family":"Laudani","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"},{"name":"Division of Cardiology, Azienda Ospedaliero\u2010Universitaria Policlinico \u2018Rodolico\u2013San Marco\u2019 University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-6010","authenticated-orcid":false,"given":"Salvatore","family":"Giordano","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"},{"name":"Division of Cardiology, Department of Medical and Surgical Sciences \u2019Magna Graecia\u2019 University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8503-5736","authenticated-orcid":false,"given":"Francesco","family":"Franchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-7347","authenticated-orcid":false,"given":"Kayla R.","family":"Tunehag","sequence":"additional","affiliation":[{"name":"Division of Cardiology and McAllister Heart Institute, School of Medicine University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Rollini","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7811-9241","authenticated-orcid":false,"given":"Selina","family":"Durukan","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7209-4348","authenticated-orcid":false,"given":"Joseph S.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Cardiology and McAllister Heart Institute, School of Medicine University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-5839","authenticated-orcid":false,"given":"Maryam","family":"Farahmandsadr","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8208-8998","authenticated-orcid":false,"given":"George A.","family":"Stouffer","sequence":"additional","affiliation":[{"name":"Division of Cardiology and McAllister Heart Institute, School of Medicine University of North 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D.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-7197","authenticated-orcid":false,"given":"Amber L.","family":"Beitelshees","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine Department of Medicine and Program for Personalized and Genomic Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3595-5301","authenticated-orcid":false,"given":"Craig R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology and McAllister Heart Institute, School of Medicine University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Division of 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