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N\u2010acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as \u201cslow acetylators\u201d) are predicted to have increased plasma hydralazine concentrations compared with NAT2 rapid and intermediate metabolizers (historically referred to as \u201crapid acetylators\u201d and \u201cintermediate acetylators,\u201d respectively), which may lead to both increased clinical efficacy and adverse effects, including drug\u2010induced systemic lupus erythematosus. 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