{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:45:52Z","timestamp":1791999952840,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019139","name":"Life Sciences, University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    Despite widespread rhFSH use in infertile women undergoing ART, real\u2010world comparative data on its effectiveness and safety across different rhFSH types remain limited. Using the HIRA claims database, we included 10,684 women aged 20\u201339 with infertility (2016\u20132021) who used only rhFSH in their first in\u00a0vitro fertilization\u2013embryo transfer (IVF\u2010ET). Outcome variables comprised effectiveness (\u2265\u200911 oocytes retrieved, pregnancy rates and live birth rate) and safety (ectopic pregnancy, miscarriage, preterm birth and ovarian hyperstimulation syndrome [OHSS]) in the whole cohort, further categorized into follitropin and other rhFSH. Baseline characteristics were described, and relative risks (RR) with 95% confidence intervals (CI) were estimated using a generalized linear model, adjusting for age and imbalanced variables. Of 10,684 patients prescribed rhFSH, 7.1% were aged 20\u201329, 41.6% were 30\u201334, and 51.3% were 35\u201339. ICSI was utilized in 57.7% of cycles, and 76.8% used the GnRH antagonist protocol. The live birth rate was 38.8%, and the OHSS rate was 5.9%. Comparing baseline characteristics of the follitropin (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092,594) and other rhFSH group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098,090), ICSI (62.2% vs. 56.3%) and GnRH antagonist protocol (81.3% vs. 75.3%) were more common in the follitropin group. Women who received follitropin were more likely to have \u2265\u200911 oocytes retrieved (adjusted RR, 1.09; 95% CI: 1.02\u20131.16) and less likely to have OHSS (adjusted RR, 0.73; 95% CI: 0.60\u20130.90). These findings provide real\u2010world evidence supporting rhFSH effectiveness and safety in fresh IVF cycles, with follitropin potentially offering advantages in oocyte retrieval and reduced OHSS rates.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70136","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:57:17Z","timestamp":1764680237000},"page":"514-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Effectiveness and Safety of Recombinant Human Follicle\u2010Stimulating Hormone (rhFSH) in Infertile Women undergoing Assisted Reproductive Technology (ART): A Korean Nationwide Cohort Study"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-3811","authenticated-orcid":false,"given":"Joong Yeup","family":"Lee","sequence":"first","affiliation":[{"name":"Hamchoon Women\u2019s Clinic  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-791X","authenticated-orcid":false,"given":"Eun\u2010Young","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"},{"name":"Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3743-2934","authenticated-orcid":false,"given":"Jung Ryeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-4822","authenticated-orcid":false,"given":"Young Sik","family":"Choi","sequence":"additional","affiliation":[{"name":"Institute of Women\u2019s Life Medical Science Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Obstetrics and Gynecology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9864-9777","authenticated-orcid":false,"given":"Ji Hyang","family":"Kim","sequence":"additional","affiliation":[{"name":"Fertility Center, CHA Bundang Women\u2019s Medical Center CHA University Bundang Medical Center  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-8029","authenticated-orcid":false,"given":"Chang\u2010Woo","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Endocrinology Female Infertility, Fertility Preservation, Seoul Maria Fertility Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7963-4242","authenticated-orcid":false,"given":"Yunju","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9182-7625","authenticated-orcid":false,"given":"Hee\u2010Jin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-9984","authenticated-orcid":false,"given":"Hyesung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Kangwon National University College of Medicine  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8626-0285","authenticated-orcid":false,"given":"Yujeong","family":"Shin","sequence":"additional","affiliation":[{"name":"Clinical &amp; Regulatory Affairs Group Life Sciences, LG Chem, Ltd.  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3780-5668","authenticated-orcid":false,"given":"Yejin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Clinical &amp; Regulatory Affairs Group Life Sciences, LG Chem, Ltd.  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-7525","authenticated-orcid":false,"given":"Ju\u2010Young","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"},{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"},{"name":"Department of Clinical Research Design and Evaluation Samsung Advanced Institute for Health Sciences &amp; Technology, Sungkyunkwan University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-6368","authenticated-orcid":false,"given":"Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Obstetrics and Gynecology Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"e_1_2_11_2_1","unstructured":"World Health Organization.Infertility prevalence estimates 1990\u20102021(2023)."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac014"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00550-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4069\/kjwhn.2021.03.12.1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-26"},{"key":"e_1_2_11_7_1","first-page":"1342","volume-title":"Clinical Gynecologic Endocrinology and Infertility","author":"Fritz M.A.","year":"2011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00727-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-023-01228-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00882-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102919"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182a603bb"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X104678"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem183"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2023.25"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.12.120"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S479700"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.05.032"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","unstructured":"ESHRE.Good clinical treatment in assisted reproduction. ESHRE position statements(2008).","DOI":"10.1093\/humrep\/den159"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead197"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05515-x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew051"},{"key":"e_1_2_11_25_1","unstructured":"Centers for Disease Control and Prevention. 2021 Assisted Reproductive Technology Fertility Clinic and National Summary Report.US Dept of Health and Human Services;2023."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.01.001"},{"key":"e_1_2_11_27_1","volume-title":"Guideline on Non\u2010Clinical and Clinical Development of Similar Biological Medicinal Products Containing Recombinant Human Follicle Stimulating Hormone (r\u2010hFSH)","author":"European Medicines Agency","year":"2013"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh181"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh206"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.047"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2025.108821"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06797-6"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx017"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08400-z"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.04.037"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.70136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:15:45Z","timestamp":1770894945000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.70136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cpt.70136"],"URL":"https:\/\/doi.org\/10.1002\/cpt.70136","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}