{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:34:37Z","timestamp":1773174877900,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031382","name":"1Florida Alzheimer's Disease Research Center","doi-asserted-by":"publisher","award":["NIH P30 AG066506"],"award-info":[{"award-number":["NIH P30 AG066506"]}],"id":[{"id":"10.13039\/100031382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 HL141690"],"award-info":[{"award-number":["K01 HL141690"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 HL172123"],"award-info":[{"award-number":["R03 HL172123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 HL172987"],"award-info":[{"award-number":["R03 HL172987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG066506"],"award-info":[{"award-number":["AG066506"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000064"],"award-info":[{"award-number":["UL1TR000064"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Hypertension is a known modifiable risk factor for Alzheimer\u2019s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD. Validated hypertension computable phenotype algorithms were applied to electronic health record data from the OneFlorida Data Trust (1\/1\/2013\u201312\/31\/2016), to identify apparent treatment\u2010resistant hypertension (aTRH), and hypertension\u2010control levels (well\u2010controlled hypertension, intermediate\u2010controlled hypertension, uncontrolled hypertension). The primary outcome was a new ADRD diagnosis using validated ICD\u20109\/10 codes. Multiple adjusted stepwise logistic regression models were used to identify factors associated with ADRD development. ADRD cumulative hazard incidence per hypertension control levels was assessed using the Nelson\u2013Aalen estimator and log\u2010rank test. A total of 57,273 hypertension patients with 6401 (11%) incident ADRD cases were included in the analysis. The average age was 67\u2009years, with 57% females and 32% identifying as Black or African American. aTRH was a significant ADRD predictor (OR: 1.327, 95% CI: 1.234\u20131.427), compared to other hypertension phenotypes. aTRH was also significantly associated with a higher incidence of ADRD over time (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Patients prescribed thiazide diuretics (OR: 0.894, 95% CI: 0.837\u20130.956) and fixed\u2010dose combination medications (OR: 0.804, 95% CI: 0.732\u20130.882) had a lower risk of ADRD. A linear relationship between SDI quartiles and ADRD risk was found. aTRH was significantly associated with the development of ADRD. Our study also highlights the importance of comprehensive hypertension control and socioeconomic interventions in preventing or reducing ADRD risk in hypertension patients.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70150","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:54:36Z","timestamp":1765266876000},"page":"751-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterizing Alzheimer\u2019s Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record\u2013Based Data"],"prefix":"10.1002","volume":"119","author":[{"given":"Eissa A.","family":"Jafari","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Department of Clinical Practice, College of Pharmacy Jazan University  Jazan Saudi Arabia"},{"name":"Center for Integrative Cardiovascular and Metabolic Disease University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-2799","authenticated-orcid":false,"given":"Mona","family":"Alshahawey","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Center for Integrative Cardiovascular and Metabolic Disease University of Florida  Gainesville Florida USA"},{"name":"Department of Clinical Pharmacy, College of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad A.","family":"Zaman","sequence":"additional","affiliation":[{"name":"School of Information Technology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Integrative Cardiovascular and Metabolic Disease University of Florida  Gainesville Florida USA"},{"name":"Department of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-1620","authenticated-orcid":false,"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-9484","authenticated-orcid":false,"given":"Glenn E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, College of Public Health and Health Professions University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6393-7288","authenticated-orcid":false,"given":"Caitrin W.","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Center for Integrative Cardiovascular and Metabolic Disease University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109998"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213954"},{"key":"e_1_2_11_4_1","volume-title":"Preventing Cognitive Decline and Dementia: A Way Forward","author":"National Academies of Sciences, Engineering, and Medicine","year":"2017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/ipm.2018.4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy288"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00096-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1646"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0724-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14993"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00283-X"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17283"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.877192"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000084"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000051"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03850"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.142"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpad084"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5095"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocab221"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooz050"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2196\/14777"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_2_11_28_1","volume-title":"ZIP Code to ZCTA Crosswalk","author":"Health Resources & Services Administration","year":"2022"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2012.01449.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1068\/b29120"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13032"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70128"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000053"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.07.015"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.821135"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2008.06.004"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2617970"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1361772"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70039"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcrp.2024.200282"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a35228"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.12.019"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2046"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.05.002"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.137"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002584"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15781"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.soc.012809.102529"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/14034948221110019"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181a6bebc"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpac063"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0568"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3543"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.70150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:10:33Z","timestamp":1771312233000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.70150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/cpt.70150"],"URL":"https:\/\/doi.org\/10.1002\/cpt.70150","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}