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Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data gaps, hindering informed treatment decisions. As long\u2010acting therapeutics transition into mainstream treatment and prevention strategies, it is critical to ensure these disparities are neither perpetuated nor widened. This review synthesizes insights from the maternal health session of the July 2025 workshop of the Community of Practice for Long\u2010Acting Therapeutics in Maternal and Pediatric Health. It was convened and hosted by the University of Liverpool Centre of Excellence for Long\u2010Acting Therapeutics with funding from Unitaid. Key themes explored during the session include (1) regulatory initiatives, research networks, and data infrastructures that are driving systemic change in maternal health research over the past two decades; (2) important efficacy and safety considerations during pregnancy and lactation using insights from long\u2010acting antiretrovirals currently in clinical use; and (3) selected long\u2010acting drug delivery systems with potential applications in maternal health. Starting with maternal health priorities, here we included further insights regarding long\u2010acting injectable antipsychotics, long\u2010acting reversible contraceptives, and the role of in silico modeling in bridging existing gaps. Several immediately actionable recommendations are presented on advancing long\u2010acting therapeutics for maternal health priorities during pregnancy and lactation.<\/jats:p>","DOI":"10.1002\/cpt.70224","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T11:40:38Z","timestamp":1770032438000},"page":"1179-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Advancing Maternal Health with Long\u2010Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-9222","authenticated-orcid":false,"given":"Rachel K.","family":"Scott","sequence":"first","affiliation":[{"name":"Women's and Children's Research Network, MedStar Health Research Institute  Washington D.C USA"},{"name":"Georgetown University School of Medicine  Washington D.C USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3419-9471","authenticated-orcid":false,"given":"Sharon","family":"Nachman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Renaissance School of Medicine, State University of New York at Stony Brook  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-3348","authenticated-orcid":false,"given":"Ethel D.","family":"Weld","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Division of Infectious Diseases, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8884-2658","authenticated-orcid":false,"given":"Rachel","family":"Daley","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Long\u2010acting Therapeutics, University of Liverpool  Liverpool UK"},{"name":"Department of Biochemistry, Cell and Systems Biology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-3753","authenticated-orcid":false,"given":"Shakir","family":"Atoyebi","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Long\u2010acting Therapeutics, University of Liverpool  Liverpool UK"},{"name":"Department of Biochemistry, Cell and Systems Biology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-2252","authenticated-orcid":false,"given":"Robert","family":"Bies","sequence":"additional","affiliation":[{"name":"Division of Pharmacokinetics, Pharmacodynamics and Systems Pharmacology, Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences, Institute for Artificial Intelligence and Data Science, University at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0134-5855","authenticated-orcid":false,"given":"Catriona","family":"Waitt","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Liverpool  Liverpool UK"},{"name":"Infectious Diseases Institute, Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-5749","authenticated-orcid":false,"given":"Adeniyi","family":"Olagunju","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Long\u2010acting Therapeutics, University of Liverpool  Liverpool UK"},{"name":"Department of Biochemistry, Cell and Systems Biology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh\u20102021\u2010007151"},{"key":"e_1_2_9_2_1","volume-title":"Trends in Maternal Mortality 2000 to 2020: Estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division","author":"World Health Organization, UNICEF, UNFPA, World Bank Group, & United Nations Population Division","year":"2023"},{"key":"e_1_2_9_3_1","unstructured":"FDA.Pregnancy Lactation and Reproductive Potential: Labeling for Human Prescription Drug and Biological Products(2020) <https:\/\/www.fda.gov\/media\/90160\/download>. 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