{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:03:30Z","timestamp":1788368610535,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Recent evidence questioned the overall safety and efficacy of colchicine in patients with coronary artery disease (CAD), as novel evidence focusing on acute coronary syndromes (ACSs) gave neutral results, while trials focusing on chronic coronary syndrome supported colchicine administration to improve long\u2010term outcomes. However, no study has ever explored whether there is a true therapeutic difference across the populations or these discrepancies are due to additional confounders. Against this background, we performed a systematic review and meta\u2010analysis of randomized trials of colchicine in patients with CAD. The primary endpoints were trial\u2010defined major adverse cardiovascular events (MACE) and serious adverse events (SAEs). Secondary endpoints included all\u2010cause death, measures of ischemia (cardiovascular death, myocardial infarction [MI], any revascularization, stroke) and measures of safety (serious infections or sepsis and gastrointestinal adverse events). All analyses included an interaction term for the clinical presentation. Sensitivity analyses were performed to explore sources of heterogeneity. After literature search, 20 trials encompassing a total of 21,486 patients (65.4% ACS) were included. Colchicine significantly reduced MACE (incidence rate ratio [IRR]: 0.70; 95% CI 0.55\u20130.87) without increasing risk for SAEs. Colchicine also reduced MI (IRR 0.81; 95% CI 0.70\u20130.94) and any revascularization (IRR 0.71; 95% CI 0.51\u20130.99), while increasing the risk of gastrointestinal adverse events (IRR 1.68; 95% CI 1.23\u20132.28). No statistically significant interaction was noted for clinical presentation for any endpoint, but a significant interaction for the drug dosage administered and the relationship with the COVID\u201019 pandemic was noted. In conclusion, the use of colchicine in patients with CAD reduces MACE without significantly increasing SAEs compared to control, although increasing gastrointestinal adverse events, without interaction by clinical presentation.<\/jats:p>","DOI":"10.1002\/cpt.70246","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:41:48Z","timestamp":1773013308000},"page":"1431-1439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and Efficacy of Colchicine across the Spectrum of Coronary Artery Disease: A\u00a0Systematic Review and Meta\u2010Analysis of 20\u00a0Randomized Trials"],"prefix":"10.1002","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-7402","authenticated-orcid":false,"given":"Claudio","family":"Laudani","sequence":"first","affiliation":[{"name":"Division of Cardiology Azienda Ospedaliero\u2010Universitaria Policlinico \u201cRodolico \u2013 San Marco\u201d, University of Catania  Catania Italy"},{"name":"Division of Cardiology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-1981","authenticated-orcid":false,"given":"Kamil","family":"Bujak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Medical University of Silesia  Katowice Poland"},{"name":"Faculty of Medical Sciences in Zabrze, 3rd Department of Cardiology Silesian Center for Heart Diseases, Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-7242","authenticated-orcid":false,"given":"Giovanni","family":"Occhipinti","sequence":"additional","affiliation":[{"name":"Institut Clinic Cardiovascular, Hospital Cl\u00ednic de Barcelona, University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-2626","authenticated-orcid":false,"given":"Riccardo","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Pulmonary Sciences Catholic University of Sacred Heart  Rome Italy"},{"name":"Cardiology Unit, Infermi Hospital  Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-6815","authenticated-orcid":false,"given":"Antonino","family":"Imbesi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Azienda Ospedaliero\u2010Universitaria Policlinico \u201cRodolico \u2013 San Marco\u201d, University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4991-6549","authenticated-orcid":false,"given":"Jorge Sanz","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Politecnico La Fe  Valencia Spain"},{"name":"Centro de Investigaci\u00f3n Biomedica en Red (CIBERCV)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-182X","authenticated-orcid":false,"given":"Mattia","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Biotechnologies Sapienza University of Rome  Latina Italy"},{"name":"Maria Cecilia Hospital, GVM Care &amp; 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