{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:02:22Z","timestamp":1789488142954,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    We evaluated whether concomitant 5\u2010aminosalicylic acid (5\u2010ASA) influences clinical remission in patients with ulcerative colitis (UC) receiving Janus kinase inhibitors (JAKi). In this retrospective, multicenter cohort study, UC patients receiving tofacitinib (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009181), upadacitinib (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009313), or filgotinib (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009139) were included. Time to clinical remission was analyzed using interval\u2010censored Cox models. Among the 633 patients treated with JAKi, 476 patients received 5\u2010ASA, and 151 did not. Cumulative probability of remission at week 48 was similar with and without 5\u2010ASA, at 81.3% and 77.0%, respectively. The adjusted hazard ratio for 5\u2010ASA vs. no 5\u2010ASA was 1.12 (95% CI 0.91\u20131.37,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.519). We therefore found that concomitant 5\u2010ASA did not significantly affect the time to clinical remission in UC patients treated with JAKi.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70256","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:46:38Z","timestamp":1773013598000},"page":"109-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concomitant 5\u2010Aminosalicylic Acid Does Not Affect the Efficacy of Janus Kinase Inhibitors in Ulcerative Colitis"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-5541","authenticated-orcid":false,"given":"Antonio","family":"Tursi","sequence":"first","affiliation":[{"name":"Territorial Gastroenterology Service, Barletta\u2010Andria\u2010Trani (BAT) Local Health Agency  Andria Italy"},{"name":"Department of Translational Medicine and Surgery, School of Medicine Catholic University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-4506","authenticated-orcid":false,"given":"Andrea","family":"Pasta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Azienda Ospedale\u2010Universit\u00e0 \u201cSan Martino\u201d, University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-0194","authenticated-orcid":false,"given":"Walter","family":"Elisei","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology A.O. \u201cS. Camillo\u2010Forlanini\u201d Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-8243","authenticated-orcid":false,"given":"Brigida","family":"Barberio","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Azienda Ospedale\u2010Universit\u00e0 di Padova (AOUP)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-7409","authenticated-orcid":false,"given":"Giammarco","family":"Mocci","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology AORN \u201cBrotzu\u201d Hospital  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-4026","authenticated-orcid":false,"given":"Giovanni","family":"Maconi","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d University Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-0115","authenticated-orcid":false,"given":"Antonietta Gerarda","family":"Gravina","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Division, Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-230X","authenticated-orcid":false,"given":"Raffaele","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Division, Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-0338","authenticated-orcid":false,"given":"Giorgia","family":"Bodini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Azienda Ospedale\u2010Universit\u00e0 \u201cSan Martino\u201d, University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":false,"given":"Edoardo Vincenzo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Azienda Ospedale\u2010Universit\u00e0 di Padova (AOUP)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-7298","authenticated-orcid":false,"given":"Alfredo","family":"Papa","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, School of Medicine Catholic University  Rome Italy"},{"name":"Digestive Diseases Centre (CEMAD), Department of Medical and Surgical Sciences, Policlinico Universitario \u201cA. Gemelli\u201d Foundation, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Italian Network for Inflammatory Bowel Diseases (IN\u2010IBD)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.06.036"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325185"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad070"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321609"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab178"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-019-03368-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16518"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.08.040"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2025.01.023"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20520"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_543_18"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117645"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341894"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518865"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.035"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.70256","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:04:21Z","timestamp":1789484661000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.70256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/cpt.70256"],"URL":"https:\/\/doi.org\/10.1002\/cpt.70256","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"assertion":[{"value":"2025-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}