{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:02:27Z","timestamp":1789488147219,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Cadmium exposure causes serious health consequences; however, there is no clinically approved antidote for cadmium poisoning. This Phase 1a\/1b trial aimed to investigate safety, tolerability, and pharmacokinetics of Sodium (S)\u20102\u2010(dithiocarboxylato((2S,3R,4R,5R)\u20102,3,4,5,6\u2010pentahydroxyhexyl) amino)\u20104\u2010(methylthio) butanoate (GMDTC), a novel chelating agent proved to eliminate cadmium through renal glucose transporters. This first\u2010in\u2010human study included two phases. Phase 1a was a randomized, double\u2010blind, single\u2010center, single\u2010dose, dose escalation trial, in which 78 eligible healthy participants aged 18\u201365\u2009years were assigned to cohorts receiving GMDTC (250, 500, 850, 1200, 1600, or 2000\u2009mg) or placebo. Thereafter, Phase 1b randomized 30 participants with elevated urinary cadmium into three groups (500, 1000, or 2000\u2009mg GMDTC), who received daily injections for 3 consecutive days, with placebo controls included in each group. During the trial, safety and tolerability were monitored for 72\u2009hour following administration. The primary endpoints included dose\u2010limiting toxicity, urinary cadmium excretion, pharmacokinetic parameters, and efficacy of GMDTC. In Phase 1a, 76 participants completed the study. No dose\u2010limiting toxicities were observed, and 169 adverse events were recorded across all cohorts, with no apparent dose\u2010related pattern or serious safety concerns. GMDTC exhibited dose\u2010proportional pharmacokinetics, with a half\u2010life of 1.25\u20132.63\u2009hour, and urinary cadmium excretion increased dose\u2010dependently within 24\u2009hour after treatment. In Phase 1b, GMDTC significantly increased 24\u2010hour urinary cadmium excretion, which positively correlated with the administered dose. GMDTC was well tolerated at doses up to 2000\u2009mg, with no serious adverse events or dose\u2010limiting toxicities. These findings support GMDTC as a novel therapeutic agent to enhance cadmium elimination in humans.<\/jats:p>","DOI":"10.1002\/cpt.70275","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:05:42Z","timestamp":1774973142000},"page":"160-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety, Tolerability, and Pharmacokinetics of\n                    <scp>GMDTC<\/scp>\n                    for Cadmium Poisoning: A Randomized Phase 1a\/1b Trial"],"prefix":"10.1002","volume":"120","author":[{"given":"Xuefeng","family":"Ren","sequence":"first","affiliation":[{"name":"Guangdong Jianersheng Pharmaceutical Technology Co., Ltd.  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