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CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines. The activity of CYP1A2 varies significantly among individuals due to genetic and non\u2010genetic factors. This GeneFocus paper offers an overview of the functional significance of CYP1A2 in drug metabolism,\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    genetic variation, and presents the updated PharmVar star allele\u2010based nomenclature for\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    . Updates include revisions to previously defined star alleles to align with PharmVar standards, as well as the addition of novel star alleles, providing the pharmacogenetic community with a more comprehensive and high\u2010quality catalog of\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    genetic variation. We highlight that the common \u2010163C&gt;A (rs762551) variant, which previously defined\n                    <jats:italic>CYP1A2*1F<\/jats:italic>\n                    , is now the sole core variant for a newly established group of\n                    <jats:italic>CYP1A2*30<\/jats:italic>\n                    alleles. Furthermore, the \u2010163C&gt;A variant, which has been associated with increased expression levels in smokers, has been found on various haplotypes in combination with one or more amino acid changing variants, each of which was assigned a unique star number (e.g.,\n                    <jats:italic>CYP1A2*13<\/jats:italic>\n                    ,\n                    <jats:italic>*21<\/jats:italic>\n                    ,\n                    <jats:italic>*24<\/jats:italic>\n                    , and\n                    <jats:italic>*31<\/jats:italic>\n                    ). While all alleles containing \u2010163C&gt;A may have increased expression levels in smokers, it remains unknown whether the presence of one or more amino acids negates the effect of increased expression levels on CYP1A2 activity. Systematic nomenclature that comprehensively describes\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    variability is essential for future research aimed at assessing the relationship between\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    variation, drug metabolism, and the clinical utility of\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    pharmacogenetic testing.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70286","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:50:46Z","timestamp":1776405046000},"page":"313-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PharmVar GeneFocus:\n                    <i>CYP1A2<\/i>\n                    \u2014Clinical Impact, Genetic Variation, and Updated 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