{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:45:05Z","timestamp":1791650705666,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    5\u2010hydroxytryptamine type 3 (5\u2010HT\n                    <jats:sub>3<\/jats:sub>\n                    ) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy\u2010induced, radiation\u2010induced, and postoperative nausea and vomiting. Most of the 5\u2010HT\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent of CYP2D6 involvement varies.\n                    <jats:italic>CYP2D6<\/jats:italic>\n                    genetic variation can influence the metabolism of these medications, particularly ondansetron and tropisetron, thereby affecting drug efficacy. This guideline is an update to the 2016 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for\n                    <jats:italic>CYP2D6<\/jats:italic>\n                    genotype and use of ondansetron and tropisetron and includes updated information on\n                    <jats:italic>CYP2D6<\/jats:italic>\n                    genetic testing and evidence tables. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for 5\u2010HT\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonists based on\n                    <jats:italic>CYP2D6<\/jats:italic>\n                    genotype, particularly where genetic variation is associated with reduced drug efficacy (updates at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.clinpgx.org\/guideline\/PA166251457\">https:\/\/www.clinpgx.org\/guideline\/PA166251457<\/jats:ext-link>\n                    ).\n                  <\/jats:p>","DOI":"10.1002\/cpt.70291","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:55:04Z","timestamp":1776174904000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Pharmacogenetics Implementation Consortium (\n                    <scp>CPIC<\/scp>\n                    ) Guideline for\n                    <i>CYP2D6<\/i>\n                    Genotype and Use of 5\u2010\n                    <scp>\n                      HT\n                      <sub>3<\/sub>\n                    <\/scp>\n                    Receptor Antagonists: 2026 Update"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-7913","authenticated-orcid":false,"given":"Claire","family":"Moore","sequence":"first","affiliation":[{"name":"Cancer Therapies Murdoch Children's Research Institute  Parkville Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Australia"},{"name":"Children's Cancer Centre, The Royal Children's Hospital  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-6102","authenticated-orcid":false,"given":"Melissa S.","family":"Bourque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-4121","authenticated-orcid":false,"given":"Andreas","family":"Halman","sequence":"additional","affiliation":[{"name":"Cancer Therapies Murdoch Children's Research Institute  Parkville Australia"},{"name":"Victorian Clinical Genetics Services, Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-9160","authenticated-orcid":false,"given":"Jos\u00e9 A. G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura University Institute of Molecular Pathology Biomarkers  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-4525","authenticated-orcid":false,"given":"Cynthia A.","family":"Prows","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Divisions of Human Genetics and Patient Services  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-2401","authenticated-orcid":false,"given":"Keiko","family":"Hikino","sequence":"additional","affiliation":[{"name":"RIKEN Center for Integrative Medical Sciences The Laboratory for Pharmacogenomics  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-075X","authenticated-orcid":false,"given":"Matthias","family":"Schwab","sequence":"additional","affiliation":[{"name":"Dr Margarete Fischer\u2010Bosch Institute of Clinical Pharmacology  Stuttgart Germany"},{"name":"Department of Clinical Pharmacology University Hospital T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Pharmacy and Biochemistry University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.","family":"Oxencis","sequence":"additional","affiliation":[{"name":"Froedtert ThedaCare Health and the Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmisha","family":"Chauhan","sequence":"additional","affiliation":[{"name":"North Thames Genomic Medicine Service Alliance  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-3650","authenticated-orcid":false,"given":"Meta H.M.","family":"Diekstra","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-451X","authenticated-orcid":false,"given":"Susie E.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Minnesota Masonic Children's Hospital  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian C.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Ochsner Health  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-1893","authenticated-orcid":false,"given":"Andrea","family":"Gaedigk","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Toxicology &amp; Therapeutic Innovation, Children's Mercy Research Institute (CMRI)  Kansas City Missouri USA"},{"name":"Department of Pediatrics University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-9312","authenticated-orcid":false,"given":"Michelle","family":"Whirl\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-6475","authenticated-orcid":false,"given":"Teri E.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Genetics Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-3793","authenticated-orcid":false,"given":"Kelly E.","family":"Caudle","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-1365","authenticated-orcid":false,"given":"Rachel","family":"Conyers","sequence":"additional","affiliation":[{"name":"Cancer Therapies Murdoch Children's Research Institute  Parkville Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Australia"},{"name":"Children's Cancer Centre, The Royal Children's Hospital  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.598"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.70108"},{"key":"e_1_2_11_3_1","unstructured":"CPIC Guideline for CYP2D6 and Ondansetron and Tropisetron: ClinPGx<https:\/\/www.clinpgx.org\/guideline\/PA166251457>."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2321"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1643"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3044"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12692"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2021.05.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31827773e9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000247340.61815.38"},{"key":"e_1_2_11_12_1","first-page":"556","article-title":"Systematic review of ondansetron for the prevention and treatment of postoperative nausea and vomiting in adults","volume":"9","author":"Cox F.","year":"1999","journal-title":"Br. J. Theatre Nurs."},{"key":"e_1_2_11_13_1","unstructured":"Canadian Agency for Drugs and Technologies in Health.Long\u2010term Use of Ondansetron Dolasetron and Granisetron for the Prevention of Nausea and Vomiting: A Review of the Clinical Effectiveness and SafetyCADTH Rapid Response Reports. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health (2014)."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0706547"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S166912"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(25)06820-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(25)08368-0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00021-Q"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(25)09187-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0472-z"},{"key":"e_1_2_11_21_1","unstructured":"Pharma M. MGI Pharma.Aloxi (palonosetron HCl injection) prescribing informationMGI Pharma (2004)."},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1994.tb04397.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1860"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31821d01bc"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.178"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.064"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13171"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/69451"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200503000-00011"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcr.2019.100266"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13447"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-06818-9"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyr117"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006288954"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112684"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0572-4"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0595-1"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.021873"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1322"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1363848"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098612454283"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.322"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.70189"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06476.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.06.016"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-132"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.70291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:17:09Z","timestamp":1783912629000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.70291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cpt.70291"],"URL":"https:\/\/doi.org\/10.1002\/cpt.70291","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}