{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:57:52Z","timestamp":1790927872338,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Antipsychotics are often prescribed in the management of behaviors and psychological symptoms of dementia. While the potential harms of antipsychotic use in people with dementia have been established, little is known about the risk associated with antipsychotic drug\u2013drug interactions (DDIs). This study aims to examine the patterns of antipsychotic DDIs and their association with 90\u2010day mortality among people with dementia using antipsychotics. This retrospective cohort study utilized Australian nationwide linked 2021 Census and Pharmaceutical Benefits Scheme data. People with dementia aged \u2265\u200965\u2009years who initiated a single antipsychotic (risperidone, quetiapine, aripiprazole, haloperidol, or olanzapine) between August 2021 and July 2022 were included. Antipsychotic DDIs were defined by Micromedex\u00ae Drug\u2010Reax, and were stratified by number, severity, and pharmacological mechanism. Mortality risk was assessed using modified Poisson regression and confounding was addressed with overlapped weighting. Among 9064 incident antipsychotic users, 6913 (76.3%) were exposed to \u2265\u20091 DDI, with the majority of them classed as \u201cmajor\u201d severity (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096709). Nervous system drugs were the most commonly interacting agents. When compared to those without antipsychotic interactions, those with \u2265\u20091 DDI had a 43% increased risk of 90\u2010day mortality (adjusted relative risk [aRR]: 1.43; 95% confidence interval [CI]: 1.22\u20131.69), while those with \u2265\u20092 DDIs had an 80% increased risk (aRR: 1.80; 95% CI: 1.49\u20132.17). Overall, antipsychotic DDIs are common among older adults with dementia and are associated with increased risk of 90\u2010day mortality. As such, medication review and regular monitoring is important when initiating antipsychotics in this vulnerable population.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70407","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:33:47Z","timestamp":1785231227000},"page":"1081-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antipsychotic Drug Interactions and Short\u2010Term Mortality Risk in People With Dementia: A National Cohort Study"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5712-2337","authenticated-orcid":false,"given":"Edward C.Y.","family":"Lau","sequence":"first","affiliation":[{"name":"The University of Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney  Sydney New South Wales 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-1501","authenticated-orcid":false,"given":"Sarah N.","family":"Hilmer","sequence":"additional","affiliation":[{"name":"Kolling Institute, Faculty of Medicine and Health, The University of Sydney and the Northern Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-9134","authenticated-orcid":false,"given":"Yun\u2010Hee","family":"Jeon","sequence":"additional","affiliation":[{"name":"Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney  Sydney New South Wales Australia"},{"name":"Ewha Womans University College of Nursing  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0575-202X","authenticated-orcid":false,"given":"Weisi","family":"Chen","sequence":"additional","affiliation":[{"name":"The University of Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-6837","authenticated-orcid":false,"given":"Christine Y.","family":"Lu","sequence":"additional","affiliation":[{"name":"The University of Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney  Sydney New South Wales Australia"},{"name":"Kolling Institute, Faculty of Medicine and Health, The University of Sydney and the Northern Sydney Local Health District  Sydney New South Wales Australia"},{"name":"Department of Pharmacy Royal North Shore Hospital  St Leonards New South Wales 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