{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:30:32Z","timestamp":1786357832099,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"abstract":"<jats:p>This study aimed to evaluate the association between tirzepatide use and the risk of carpal tunnel syndrome (CTS) and CTS surgery compared with both glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) and other anti\u2010obesity medications in individuals who are overweight or obese. We conducted a multicenter retrospective cohort study using the TriNetX US Collaborative Network with a target trial emulation design. Adults aged \u2265\u200918\u2009years who are overweight or obese and initiated tirzepatide, GLP\u20101RAs, or other anti\u2010obesity medications (including orlistat or phentermine) between January 2022 and December 2024 were included. Propensity score matching (1:1) was applied to balance demographics, BMI, comorbidities, and socioeconomic variables. Primary outcomes were incident CTS and CTS surgery, with hazard ratios (HRs) and 95% confidence intervals (CIs) estimated. Sensitivity analyses varied lag periods, follow\u2010up durations, analytical frameworks, and matching strategies, while subgroup analyses examined age, sex, race, BMI, and diabetes status. The study complied with the Declaration of Helsinki and received IRB exemption (#11312\u2010E01 and #11212\u2010E02). After matching, well\u2010balanced cohorts were achieved across comparisons. Tirzepatide use was associated with a significantly lower risk of CTS compared with GLP\u20101RAs (HR 0.82; 95% CI 0.71\u20130.95), with no significant difference in CTS surgery. In comparison with other anti\u2010obesity medications, tirzepatide was associated with reduced risks of both CTS (HR 0.75; 95% CI 0.65\u20130.85) and CTS surgery (HR 0.64; 95% CI 0.44\u20130.94). In conclusion, Tirzepatide use was associated with reduced risks of CTS, particularly when compared with non\u2013GLP\u20101RA therapies, suggesting potential metabolic and neuroprotective benefits.<\/jats:p>","DOI":"10.1002\/cpt.70440","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:47:35Z","timestamp":1786355255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tirzepatide Use Is Associated with Reduced Risk of Carpal Tunnel Syndrome in Overweight and Obese Adults"],"prefix":"10.1002","author":[{"given":"Yu\u2010Jung","family":"Su","sequence":"first","affiliation":[{"name":"Orthopedics Department Chi\u2010Mei Medical Center  Tainan Taiwan"},{"name":"Institute of Biomedical Sciences National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-5635","authenticated-orcid":false,"given":"Shuo\u2010Yan","family":"Gau","sequence":"additional","affiliation":[{"name":"Department of Medical Education Ditmanson Medical Foundation Chia\u2010Yi Christian Hospital  Chiayi City Taiwan"},{"name":"Institute of Allergology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department and Graduate Institute of Business Administration National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yow\u2010Ling","family":"Shiue","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Institute of Precision Medicine, College of Medicine National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_13_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00432-X"},{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.70024"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097499"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00521-1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.17712\/1658-3183.2112"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44060181"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12324"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsg.2025.01.016"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061510"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2024.101545"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.27258"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-05066-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14353"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.10.055"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13716"},{"key":"e_1_2_13_16_1","article-title":"Glucagon\u2010like Peptide\u20101 receptor agonist therapy associated with fewer diagnoses of carpal tunnel syndrome within 2\u2009years of treatment","volume":"21","author":"Hiredesai A.N.","year":"2025","journal-title":"Hand"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0299442"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.688849"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-025-01649-z"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1146960"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.069"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1626103"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwae226"}],"container-title":["Clinical Pharmacology &amp; 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