{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:28:19Z","timestamp":1787041699143,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR21\/00066"],"award-info":[{"award-number":["JR21\/00066"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM23\/00126"],"award-info":[{"award-number":["CM23\/00126"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR25\/00027"],"award-info":[{"award-number":["JR25\/00027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FORT23\/00013"],"award-info":[{"award-number":["FORT23\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PT23\/00137"],"award-info":[{"award-number":["PT23\/00137"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24\/01205"],"award-info":[{"award-number":["PI24\/01205"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB07\/04\/2008"],"award-info":[{"award-number":["CB07\/04\/2008"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP25\/00033"],"award-info":[{"award-number":["CP25\/00033"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01248"],"award-info":[{"award-number":["PI21\/01248"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["A1\u20100025\u20102025"],"award-info":[{"award-number":["A1\u20100025\u20102025"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PPRO\u2010CTS1032\u2010G\u20102023"],"award-info":[{"award-number":["PPRO\u2010CTS1032\u2010G\u20102023"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["Cl.2\u20100001\u20102025"],"award-info":[{"award-number":["Cl.2\u20100001\u20102025"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PPRO\u2010CTS649\u2010G\u20102023"],"award-info":[{"award-number":["PPRO\u2010CTS649\u2010G\u20102023"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["B\u20100006\/2024"],"award-info":[{"award-number":["B\u20100006\/2024"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"abstract":"<jats:p>\n                    Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug\u2010induced liver injury (DILI) is still scarce. We aimed to ascertain the incidence, clinical profile, culprit drugs, and prognosis associated with concomitant DILI and AKI. We include patients from two long\u2010term prospective DILI registries, the Spanish DILI registry and the Latin American DILI (LATINDILI) Network. Demographics, clinical characteristics, and outcome of patients with DILI\u2010AKI were compared to those patients with DILI and without AKI. Overall, 54 out of 978 patients had AKI at the time of DILI diagnosis (5.5%). The most frequent culprit drug implicated in DILI\u2010AKI was amoxicillin\u2013clavulanate (11%) followed by anabolic androgenic steroids, antituberculosis drugs, ebrotidine, and ticlopidine (5.5% each). DILI\u2010AKI cases were older than patients without AKI (60\u2009\u00b1\u200918 vs. 52\u2009\u00b1\u200918;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001), and mostly men (63%;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.022). Furthermore, DILI\u2010AKI cases showed higher comorbidity burden, and cholestatic damage and lymphopenia were more prevalent. Notably, DILI\u2010AKI cases had higher incidence of liver\u2010related death and all\u2010cause mortality than those patients with no renal dysfunction (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.029 and\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.015, respectively). In both a multivariable logistic regression (odds ratio [OR]\u2009=\u20093.46; 95% confidence interval [CI] 1.39\u20138.59;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.008), and a rigorous propensity score\u2010matched analysis (OR\u2009=\u20095.20; 95% CI 1.06\u201325.52;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.042), renal damage was found as a risk factor of poor outcome. In conclusion, AKI in DILI mostly occurs in older male patients with cholestatic injury, lymphopenia, and greater burden of comorbidities, but mortality is restricted to DILI\u2010AKI patients with hepatocellular damage. Overall, AKI is a risk factor of poor outcome in idiosyncratic DILI.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70452","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:08:13Z","timestamp":1787040493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug\u2010Induced Liver Injury: A Multicentric Propensity Scores Matched Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-9573","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Pinazo\u2010Bandera","sequence":"first","affiliation":[{"name":"Service of Gastroenterology and Hepatology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-3972","authenticated-orcid":false,"given":"Hao","family":"Niu","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Service of Clinical Farmacology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-7193","authenticated-orcid":false,"given":"Juan Pedro","family":"Toro\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Service of Gastroenterology and Hepatology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-6658","authenticated-orcid":false,"given":"Inmaculada","family":"Medina\u2010Caliz","sequence":"additional","affiliation":[{"name":"Service of Clinical Farmacology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7769-7008","authenticated-orcid":false,"given":"Judith","family":"Sanabria\u2010Cabrera","sequence":"additional","affiliation":[{"name":"Service of Clinical Farmacology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-4093","authenticated-orcid":false,"given":"A\u00edda","family":"Ortega\u2010Alonso","sequence":"additional","affiliation":[{"name":"Service of Gastroenterology and Hepatology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-2787","authenticated-orcid":false,"given":"Mercedes","family":"Robles\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Service of Clinical Farmacology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-0518","authenticated-orcid":false,"given":"Daniel Enrique","family":"Di Zeo\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Service of Clinical Farmacology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6816-3699","authenticated-orcid":false,"given":"Nelia","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Cl\u00ednicas Hospital  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-8123","authenticated-orcid":false,"given":"Fernando","family":"Bessone","sequence":"additional","affiliation":[{"name":"Centenario Hospital, Rosario National University  Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-9526","authenticated-orcid":false,"given":"Vinicius","family":"Nunes","sequence":"additional","affiliation":[{"name":"Prof. Edgard Santos\u2010UFBA University Hospital  Salvador de Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-4597","authenticated-orcid":false,"given":"Raymundo","family":"Paran\u00e1","sequence":"additional","affiliation":[{"name":"Prof. Edgard Santos\u2010UFBA University Hospital  Salvador de Bahia Brazil"},{"name":"School of Medicine Universidad Nacional de Bahia  Salvador de Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-4896","authenticated-orcid":false,"given":"M. Isabel","family":"Lucena","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Service of Clinical Farmacology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-0757","authenticated-orcid":false,"given":"Raul J.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Service of Gastroenterology and Hepatology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-0604","authenticated-orcid":false,"given":"Ismael","family":"Alvarez\u2010Alvarez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Service of Clinical Farmacology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0410-8273","authenticated-orcid":false,"given":"Miren","family":"Garc\u00eda\u2010Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Service of Gastroenterology and Hepatology, University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma Bionand Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dico en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL clinical practice guidelines: drug\u2010induced liver injury","volume":"70","author":"European Association for the Study of the Liver","year":"2019","journal-title":"J. Hepatol."},{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(24)02385-7","article-title":"Acute kidney injury","volume":"405","author":"Ostermann M.","year":"2025","journal-title":"Lancet"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2215\/CJN.03040322","article-title":"Acute kidney injury in patients with liver disease","volume":"17","author":"Cullaro G.","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.jhep.2023.07.010","article-title":"Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US","volume":"79","author":"Patidar K.R.","year":"2023","journal-title":"J. Hepatol."},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002040","article-title":"Risk of acute kidney injury and long\u2010term outcome in patients with acetaminophen intoxication: a nationwide population\u2010based retrospective cohort study","volume":"94","author":"Chen Y.G.","year":"2015","journal-title":"Medicine"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jhep.2021.01.029","article-title":"Comprehensive analysis and insights gained from long\u2010term experience of the Spanish DILI registry","volume":"75","author":"Stephens C.","year":"2021","journal-title":"J. Hepatol."},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cgh.2024.06.030","article-title":"Drug\u2010induced liver injury in Latin America: 10\u2010year experience of the Latin American DILI (LATINDILI) network","volume":"23","author":"Bessone F.","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0895-4356(93)90101-6","article-title":"Causality assessment of adverse reactions to drugs\u2010\u2010I. A novel method based on the conclusions of international consensus meetings: application to drug\u2010induced liver injuries","volume":"46","author":"Danan G.","year":"1993","journal-title":"J. Clin. Epidemiol."},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/clpt.2011.58","article-title":"Case definition and phenotype standardization in drug\u2010induced liver injury","volume":"89","author":"Aithal G.P.","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/j.gastro.2014.03.050","article-title":"Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug\u2010induced liver injury","volume":"147","author":"Robles\u2010Diaz M.","year":"2014","journal-title":"Gastroenterology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson M.","year":"1994","journal-title":"J. Clin. Epidemiol."},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja A.","year":"2012","journal-title":"Nephron Clin. Pract."},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","author":"Kidney Disease: Improving global outcomes CKDWG","year":"2024","journal-title":"Kidney Int."},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine\u2010 and cystatin C\u2010based equations to estimate GFR without race","volume":"385","author":"Inker L.A.","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/pst.433","article-title":"Optimal caliper widths for propensity\u2010score matching when estimating differences in means and differences in proportions in observational studies","volume":"10","author":"Austin P.C.","year":"2011","journal-title":"Pharm. Stat."},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0168-8278(99)80343-2","article-title":"Acute liver injury associated with the use of ebrotidine, a new H2\u2010receptor antagonist","volume":"31","author":"Andrade R.J.","year":"1999","journal-title":"J. Hepatol."},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1053\/j.gastro.2015.03.006","article-title":"Features and outcomes of 899 patients with drug\u2010induced liver injury: the DILIN prospective study","volume":"148","author":"Chalasani N.","year":"2015","journal-title":"Gastroenterology"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/ajg.2012.138","article-title":"A prospective nationwide study of drug\u2010induced liver injury in Korea","volume":"107","author":"Suk K.T.","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/hepr.13288","article-title":"Analysis of 307 cases with drug\u2010induced liver injury between 2010 and 2018 in Japan","volume":"49","author":"Aiso M.","year":"2019","journal-title":"Hepatol. Res."},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jceh.2020.11.002","article-title":"The Indian network of drug\u2010induced liver injury: etiology, clinical features, outcome and prognostic markers in 1288 patients","volume":"11","author":"Devarbhavi H.","year":"2021","journal-title":"J. Clin. Exp. Hepatol."},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41581-024-00868-4","article-title":"Pathological mechanisms of kidney disease in ageing","volume":"20","author":"Yamamoto T.","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051018","article-title":"Drug\u2010induced liver injury: cascade of events leading to cell death, apoptosis or necrosis","volume":"18","author":"Iorga A.","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12829","article-title":"TNF\u2010alpha\/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury","volume":"53","author":"Wang Y.","year":"2020","journal-title":"Cell Prolif."},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1002\/hep.30499","article-title":"Cholemic nephropathy causes acute kidney injury and is accompanied by loss of aquaporin 2 in collecting ducts","volume":"69","author":"Br\u00e4sen J.H.","year":"2019","journal-title":"Hepatology"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0168-8278(95)80428-5","article-title":"Aminoglycoside\u2010associated nephrotoxicity in extrahepatic obstructive jaundice","volume":"22","author":"Lucena M.I.","year":"1995","journal-title":"J. Hepatol."},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/apt.13023","article-title":"Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids","volume":"41","author":"Robles\u2010Diaz M.","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"e_1_2_9_27_1","first-page":"939","article-title":"Albumin dialysis with MARS for the treatment of anabolic steroid\u2010induced cholestasis","volume":"15","author":"Diaz F.C.","year":"2016","journal-title":"Ann. Hepatol."},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1080\/0886022X.2022.2079521","article-title":"Monocyte\u2010to\u2010lymphocyte ratio: a potential novel predictor for acute kidney injury in the intensive care unit","volume":"44","author":"Jiang F.","year":"2022","journal-title":"Ren. Fail."},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16191","article-title":"Genetic and genomic approaches to the study of drug\u2010induced liver injury","volume":"45","author":"Daly A.K.","year":"2025","journal-title":"Liver Int."},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113664","article-title":"Clinical prospects of biomarkers for the early detection and\/or prediction of organ injury associated with pharmacotherapy","volume":"170","author":"Tajima S.","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000359","article-title":"Urinary NGAL as a diagnostic and prognostic marker for acute kidney injury in cirrhosis: a prospective study","volume":"12","author":"Allegretti A.S.","year":"2021","journal-title":"Clin. Transl. Gastroenterol."}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpt.70452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt.70452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:08:18Z","timestamp":1787040498000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.70452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":31,"alternative-id":["10.1002\/cpt.70452"],"URL":"https:\/\/doi.org\/10.1002\/cpt.70452","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cpt.70452"}}