{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:13:07Z","timestamp":1788257587865,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UC2HD113041"],"award-info":[{"award-number":["UC2HD113041"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"abstract":"<jats:p>\n                    Solute carriers (\n                    <jats:italic>SLC<\/jats:italic>\n                    ) and ATP\u2010binding cassette (\n                    <jats:italic>ABC<\/jats:italic>\n                    ) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear. Using RNA sequencing, we profiled\n                    <jats:italic>SLC<\/jats:italic>\n                    and\n                    <jats:italic>ABC<\/jats:italic>\n                    transporter expression in two anatomical regions of term human placentas (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200910) with balanced fetal sex distribution and controlled clinical features. In the intervillous region, 276\n                    <jats:italic>SLC<\/jats:italic>\n                    s were detected, with 60% expressed at low levels (CPM\u2009&lt;\u200925) and 110 (40%) expressed at higher levels (CPM 25\u20131650). Four transporters\u2014\n                    <jats:italic>SLC2A1<\/jats:italic>\n                    (GLUT1),\n                    <jats:italic>SLC44A2<\/jats:italic>\n                    (CTL2),\n                    <jats:italic>SLC38A2<\/jats:italic>\n                    (SNAT2), and\n                    <jats:italic>SLC38A1<\/jats:italic>\n                    (SNAT1)\u2014showed the highest expression (CPM\u2009&gt;\u2009500). Functional annotation of 110\n                    <jats:italic>SLC<\/jats:italic>\n                    s revealed transporters for amino acids, metals, and inorganic ions each accounted for ~9%. Other well\u2010represented\n                    <jats:italic>SLC<\/jats:italic>\n                    s included xenobiotic and vitamin transporters. Mitochondrial, lysosomal, and endoplasmic reticulum and Golgi transporters together accounted for ~37%, while 11% were orphan transporters. Thirty\u2010seven\n                    <jats:italic>ABC<\/jats:italic>\n                    transporter transcripts were detected, primarily associated with xenobiotic and lipid transport. Compared with the intervillous region, 1676 genes\u2014including 32\n                    <jats:italic>SLC<\/jats:italic>\n                    and 2\n                    <jats:italic>ABC<\/jats:italic>\n                    transporters\u2014were differentially expressed in the decidual region. Although 117 genes in the intervillous region and 79 genes in the decidual region exhibited sexually dimorphic expression, none were\n                    <jats:italic>SLC<\/jats:italic>\n                    s. Notably, male placentas showed higher expression of\n                    <jats:italic>ABCB1<\/jats:italic>\n                    (P\u2010gp), confirmed by qPCR and western blot. Our findings provide a transcriptomic map of placental transporters and highlight a potential sex\u2010specific difference on\n                    <jats:italic>ABCB1<\/jats:italic>\n                    expression and xenobiotic protection.\n                  <\/jats:p>","DOI":"10.1002\/cpt.70463","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:15:50Z","timestamp":1788254150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic Profiling of\n                    <scp>SLC<\/scp>\n                    and\n                    <scp>ABC<\/scp>\n                    Transporters in the Human Term Placenta"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7678-6711","authenticated-orcid":false,"given":"Elijah Marsh","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-8230","authenticated-orcid":false,"given":"Nicholas","family":"Ieronimakis","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN Madigan Army Medical Center  Tacoma Washington USA"},{"name":"Department of Clinical Investigation Madigan Army Medical Center  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4417-4479","authenticated-orcid":false,"given":"Bothaina","family":"Mousa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily D.","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN Madigan Army Medical Center  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Ligon","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN Madigan Army Medical Center  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua W.","family":"Monson","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN Madigan Army Medical Center  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9764-0188","authenticated-orcid":false,"given":"Jennifer R.","family":"Damicis","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation Madigan Army Medical Center  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7002-5607","authenticated-orcid":false,"given":"Hillary J.","family":"Kinsman","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation Madigan Army Medical Center  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia E.","family":"Bettridge","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation Madigan Army Medical Center  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-2347","authenticated-orcid":false,"given":"Samuel L.M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-9313","authenticated-orcid":false,"given":"Edward J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-8455","authenticated-orcid":false,"given":"Jashvant D.","family":"Unadkat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-9101","authenticated-orcid":false,"given":"Joanne","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/AOG.0000000000002579","article-title":"Prescription and other medication use in pregnancy","volume":"131","author":"Haas D.M.","year":"2018","journal-title":"Obstet. 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