{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:05:19Z","timestamp":1790766319997,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Pharma and Therapeutics"],"abstract":"<jats:p>Commercial laboratories often have differing approaches to pharmacogenomic testing, which detects the presence of germline genetic variants associated with drug response. Setting standards for clinical laboratories and defining criteria for clinicians to consider when choosing a testing laboratory can help maximize the benefits of pharmacogenomics. Here, we propose specific laboratory practices that should be discontinued or established and followed as standard practice. We also propose ideal practices that would advance pharmacogenomics in clinical care.<\/jats:p>","DOI":"10.1002\/cpt.70507","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:49:32Z","timestamp":1790765372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Problems and Adhering to Standards: A Pathway to Uniform Clinical Laboratory Processes that Maximize the Benefits of Pharmacogenomics"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-2373","authenticated-orcid":false,"given":"Elizabeth","family":"Fieg","sequence":"first","affiliation":[{"name":"Baylor Genetics  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9402-2054","authenticated-orcid":false,"given":"Ben","family":"Kerman","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Genetics and Genomic Medicine Service Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-8209","authenticated-orcid":false,"given":"Lucas A.","family":"Berenbrok","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Therapeutics University of Pittsburgh School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Frear","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Massachusetts College of Pharmacy and Health Sciences  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Marcath","sequence":"additional","affiliation":[{"name":"Baylor Genetics  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-7957","authenticated-orcid":false,"given":"Mylynda","family":"Massart","sequence":"additional","affiliation":[{"name":"UPMC Primary Care Precision Medicine Clinic  Pittsburgh Pennsylvania USA"},{"name":"School of Public Health, Department of Human Genetics University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Clinical Translational Science Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Family Medicine School of Medicine, University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Berman","sequence":"additional","affiliation":[{"name":"UPMC Primary Care Precision Medicine Clinic  Pittsburgh Pennsylvania USA"},{"name":"School of Public Health, Department of Human Genetics University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/cpt.3704","article-title":"Navigating pharmacogenomic testing in practice: who to test and when to test","volume":"118","author":"Stevenson J.M.","year":"2025","journal-title":"Clin. Pharmacol. Ther."},{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5858\/arpa.2025-0179-CP","article-title":"Pharmacogenomic testing: strategies and technical considerations for clinical laboratories","volume":"150","author":"Yuan J.","year":"2026","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.gim.2021.12.009","article-title":"Clinical pharmacogenomic testing and reporting: a technical standard of the American College of Medical Genetics and Genomics (ACMG)","volume":"24","author":"Tayeh M.K.","year":"2022","journal-title":"Genet. 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Accessed March 11 2026."},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/phar.1985","article-title":"Pharmacogenomics implementation: considerations for selecting a reference laboratory","volume":"37","author":"Vo T.T.","year":"2017","journal-title":"Pharmacotherapy"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3343\/alm.2024.0652","article-title":"Pharmacogenomic testing in the clinical laboratory: historical progress and future opportunities","volume":"45","author":"Moyer A.M.","year":"2025","journal-title":"Ann. Lab. 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